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knime2021 targets valid

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filips edited this page Dec 9, 2021 · 1 revision

validated protein targets with great number of IC50 activities available in the chembl

  1. Epidermal growth factor receptor erbB1
  2. Vascular endothelial growth factor receptor 2
  3. Serine/threonine-protein kinase mTOR
  4. MAP kinase p38 alpha
  5. Tyrosine-protein kinase JAK2
  6. Tyrosine-protein kinase receptor FLT3
  7. Serine/threonine-protein kinase B-raf
  8. Stem cell growth factor receptor
  9. Hepatocyte growth factor receptor
  10. Tyrosine-protein kinase SRC
  11. Serine/threonine-protein kinase PIM1
  12. Tyrosine-protein kinase LCK
  13. Glycogen synthase kinase-3 beta
  14. Serine/threonine-protein kinase AKT
  15. Insulin-like growth factor I receptor
  16. Fibroblast growth factor receptor 1
  17. Serine/threonine-protein kinase Aurora-A
  18. Tyrosine-protein kinase JAK1
  19. Tyrosine-protein kinase JAK3
  20. Receptor protein-tyrosine kinase erbB-2
  21. Tyrosine-protein kinase SYK
  22. Tyrosine-protein kinase BTK
  23. Cyclin-dependent kinase 2
  24. Nerve growth factor receptor Trk-A
  25. Serine/threonine-protein kinase Chk1
  26. ALK tyrosine kinase receptor
  27. Vascular endothelial growth factor receptor 1
  28. Rho-associated protein kinase 2
  29. Protein kinase C alpha
  30. Serine/threonine-protein kinase PIM2
  31. Fibroblast growth factor receptor 3
  32. Insulin receptor
  33. Inhibitor of nuclear factor kappa B kinase beta subunit
  34. Leucine-rich repeat serine/threonine-protein kinase 2
  35. Interleukin-1 receptor-associated kinase 4
  36. Platelet-derived growth factor receptor beta
  37. Macrophage colony stimulating factor receptor
  38. MAP kinase-activated protein kinase 2
  39. Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  40. MAP kinase ERK1
  41. c-Jun N-terminal kinase 1
  42. Rho-associated protein kinase 1
  43. c-Jun N-terminal kinase 2
  44. Ribosomal protein S6 kinase 1
  45. Tyrosine-protein kinase TYK2
  46. Focal adhesion kinase 1
  47. Serine/threonine-protein kinase PIM3
  48. Serine/threonine-protein kinase RAF
  49. Cyclin-dependent kinase 1
  50. 3-phosphoinositide dependent protein kinase-1
  51. Tyrosine-protein kinase ITK/TSK
  52. PAS domain-containing serine/threonine-protein kinase
  53. TGF-beta receptor type I
  54. Maternal embryonic leucine zipper kinase
  55. Tyrosine-protein kinase TIE-2
  56. Ephrin type-B receptor 4

Computer Aided Drug Design @ Politechnika Warszawska, Filip Stefaniak

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