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HIST1H3B

rdmorin edited this page Jan 16, 2025 · 29 revisions

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @lohrDiscoveryPrioritizationSomatic2012, @reichelFlowSortingExome2015,

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Overview

The relevance of HIST1H3B mutations in DLBCL remains unclear. Selective pressure analysis did not identify this gene as significantly enriched for either missense or truncating mutations, indicating that many of these mutations may represent passengers.

Relevance tier by entity

include:tables/table1_HIST1H3B.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_HIST1H3B.md

BL

include:tables/BL_HIST1H3B.md

FL

include:tables/FL_HIST1H3B.md

Mutation pattern and selective pressure estimates

include:tables/dnds_HIST1H3B.md

HIST1H3B Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr6 26032045 C>T D82N
chr6 26032029 C>G S87T
chr6 26032029 C>T S87N
chr6 26032028 G>C S87R
chr6 26032021 C>T V90M
chr6 26032017 A>G M91T

include:tables/browser_HIST1H3B.md

include:tables/mermaid_HIST1H3B.md

References

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