Pairwise-ComBat is an extention of ComBat, an harmonization method often used in MRI imaging. The main caracteristic of Pairwise-ComBat is that is harmonizes together a pair of sites, i.e. a "moving site" that is aligned onto a "target site". Please refer to Figure 1 a) and j) for an illustration.
This is different from ComBat which harmonizes of a group of
For more details on Pairwise-ComBat, please refer and cite the following paper
| Paper to cite | Paper Link | |
|---|---|---|
| Pairwise-ComBat | M. Edde, G.Girard, Y. David, M. Descoteaux, P-M Jodoin. Challenges and best practices when using ComBAT to harmonize diffusion MRI data. Nature Scientific Reports:15, Article number:41508, 2025. | Nature SR Link arxiv link |
Please note that the code on this repo is a revisited version of Jean-Philippe Fortin's original work.
The original version of ComBAT is described in the following seminal papers
| Papers | Paper Link | |
|---|---|---|
| ComBat for multi-site DTI data | Jean-Philippe Fortin, Drew Parker, Birkan Tunc, Takanori Watanabe, Mark A Elliott, Kosha Ruparel, David R Roalf, Theodore D Satterthwaite, Ruben C Gur, Raquel E Gur, Robert T Schultz, Ragini Verma, Russell T Shinohara. Harmonization Of Multi-Site Diffusion Tensor Imaging Data. NeuroImage, 161, 149-170, 2017 | Link |
| ComBat for multi-site cortical thickness measurements | Jean-Philippe Fortin, Nicholas Cullen, Yvette I. Sheline, Warren D. Taylor, Irem Aselcioglu, Philip A. Cook, Phil Adams, Crystal Cooper, Maurizio Fava, Patrick J. McGrath, Melvin McInnis, Mary L. Phillips, Madhukar H. Trivedi, Myrna M. Weissman, Russell T. Shinohara. Harmonization of cortical thickness measurements across scanners and sites. NeuroImage, 167, 104-120, 2018 | Link |
| Original ComBat paper for gene expression array | W. Evan Johnson and Cheng Li, Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics, 8(1):118-127, 2007. | Link |