Computational biologist with a deep interest in generative models for gene regulation, synthetic biology, and understanding the wild mechanisms of the genome.
<pjsample [at] gmail [dot] com>
Human 5′ UTR Design and Variant Effect Prediction from a Massively Parallel Translation Assay
Paul J Sample, Ban Wang, David W Reid, Vlad Presnyak, Iain J McFadyen, David R Morris, Georg Seelig
Nature Biotechnology, 2019
Single-Cell Profiling of the Developing Mouse Brain and Spinal Cord with Split-Pool Barcoding
Alexander B Rosenberg, Charles M Roco, Richard A Muscat, Anna Kuchina, Paul J Sample, Zizhen Yao, Lucas T Graybuck, David J Peeler, Sumit Mukherjee, Wei Chen, et al.
Science, 2018
Multimodal Circulating Tumor DNA (ctDNA) Colorectal Neoplasia Detection Assay for Asymptomatic and Early-Stage Colorectal Cancer (CRC)
Jeeyun Lee, Hee C Kim, Seung Tae Kim, Yupeng He, Paul J Sample, Yoshiaki Nakamura, Victoria M Raymond, Ariel Jaimovich, AmirAli Talasaz
Journal of Clinical Oncology 39, 2021
Integrated Genomic and Epigenomic Cell-Free DNA (cfDNA) Analysis for the Detection of Early-Stage Colorectal Cancer
Oscar Westesson, Haley Axelrod, Jason Dean, Yupeng He, Paul Sample, Elena Zotenko, Ruth McCole, Mohit Goel, Charbel Eid, Jessica Kurata, et al.
AACR, 2020
Multimodal Circulating Tumor DNA (ctDNA) Blood-Based Colorectal Cancer (CRC) Screening Test Demonstrates Clinically Meaningful Sensitivity Across Multiple Clinical Parameters
Hee Cheol Kim, Seung Tae Kim, Yupeng He, Paul J Sample, Victoria Raymond, Ariel Jaimovich, AmirAli Talasaz, Jeeyun Lee
Official journal of the American College of Gastroenterology, 2021
A Common tRNA Modification at an Unusual Location: The Discovery of Wyosine Biosynthesis in Mitochondria
Paul J Sample, Luděk Kořený, Zdeněk Paris, Kirk W Gaston, Mary Anne T Rubio, Ian MC Fleming, Scott Hinger, Eva Horáková, Patrick A Limbach, Julius Lukeš, et al.
Nucleic Acids Research, 2015
RoboOligo: Software for Mass Spectrometry Data to Support Manual and de Novo Sequencing of Post-Transcriptionally Modified Ribonucleic Acids
Paul J Sample, Kirk W Gaston, Juan D Alfonzo, Patrick A Limbach
Nucleic Acids Research, 2015
Unusual Noncanonical Intron Editing Is Important for tRNA Splicing in Trypanosoma Brucei
Mary Anne T Rubio, Zdeněk Paris, Kirk W Gaston, Ian MC Fleming, Paul J Sample, Christopher R Trotta, Juan D Alfonzo
Molecular Cell, 2013
tRNA Biogenesis and Processing
Jessica L Spears, Mary Anne T Rubio, Paul J Sample, Juan D Alfonzo
RNA Metabolism in Trypanosomes, 99-121, 2012, Springer
The T. Brucei TRM5 Methyltransferase Plays an Essential Role in Mitochondrial Protein Synthesis and Function
Zdeněk Paris, Eva Horáková, Mary Anne T Rubio, Paul J Sample, Ian MC Fleming, Stephanie Armocida, Julius Lukeš, Juan D Alfonzo
RNA, 2013