Skip to content

Commit

Permalink
missed changes. (#94)
Browse files Browse the repository at this point in the history
  • Loading branch information
jdstamp authored Dec 1, 2022
1 parent be3622d commit c6e8133
Showing 1 changed file with 2 additions and 2 deletions.
4 changes: 2 additions & 2 deletions DESCRIPTION
Original file line number Diff line number Diff line change
Expand Up @@ -18,8 +18,8 @@ Description: Epistasis, commonly defined as the interaction between genetic loci
between a given variant and all other variants. By searching for marginal epistatic effects, one can identify genetic
variants that are involved in epistasis without the need to identify the exact partners with which the variants
interact – thus, potentially alleviating much of the statistical and computational burden associated with
conventional explicit search based methods. Our proposed mvMAPIT builds upon this strategy by taking of correlation
structures between traits to improve the identification of variants involved in epistasis. We formulate mvMAPIT as a
conventional explicit search based methods. Our proposed mvMAPIT builds upon this strategy by taking advantage of
correlation structure between traits to improve the identification of variants involved in epistasis. We formulate mvMAPIT as a
multivariate linear mixed model and develop a multi-trait variance component estimation algorithm for efficient
parameter inference and P-value computation. Together with reasonable model approximations, our proposed approach is
scalable to moderately sized GWA studies.
Expand Down

0 comments on commit c6e8133

Please sign in to comment.