Installing IEDB MHC tools

Introduction

The distributions 'IEDB_MHC*.tar.gz' contain a collection of peptide binding prediction tools for Major Histocompatibility Complex (MHC) class I and II molecules. The collection is a mixture of pythons scripts and linux 32-bit environment specific binaries.

Prerequisites:

Linux environment is recommended.

Under ubuntu you should install tcsh and gawk: sudo apt-get install tcsh gawk

Installation:

Download from http://tools.iedb.org/mhcii/download/. Unpack the tar.gz files. Run the 'configure' script to set up path variables for trained models.

For MHC-II tools:

  $ tar -zxvf IEDB_MHC_II-2.16.3.tar.gz
  $ cd mhc_ii
  $ ./configure.py

Available prediction methods are:

• comblib
• consensus3
• IEDB_recommended
• NetMHCIIpan
• nn_align
• smm_align
• sturniolo

For MHC-I tools:

Same as above, but download from See http://tools.iedb.org/mhci/download/

Available methods are:

• ann
• comblib_sidney2008
• consensus
• IEDB_recommended
• netmhcpan
• smm
• smmpmbec