2025 Goal(2025/6/1 - 2025/12/31): Master AlphaFold 3 by thoroughly studying its research paper and codebase in the shortest time possible, then leverage it to design novel drugs targeting currently incurable diseases.
Once you build a powerful physique through hard training, with such strength and determination, what can’t you achieve ?
"When the term ‘devil coach’ is mentioned, many think of German football manager Felix Magath, who was infamous for his merciless physical training regimens. Norwegian striker Jan Åge Fjørtoft once remarked on Magath’s extreme training demands: ‘I don’t know if Magath could have saved the Titanic, but if he had been aboard, every passenger would have survived—by swimming all the way back to Southampton.’"
When you read a book, a paper or source code, you are communicating with the brightest minds in human history. This is actually the most "effective" way to communicate. This is also the quickest path to success.
Extroverted and cheerful individuals always adapt to new environments and embrace new challenges more easily than introverted ones.
Since you believe that your introverted personality has caused many setbacks and failures in your life, then actively change your personality!
Since you regard a weak body as an obstacle to your success, be proactive about exercising so you can build a strong, healthy physique.
In order to be able to do 100 consecutive pull-ups, you need to train yourself to hang on the bar for as long as possible.
feat: 2025/6/5, 60 Five-Finger Push-Ups in a row(All five fingers of each hand are spread and bear the weight. You perform a push-up with only your fingers touching the ground (instead of your palms))
feat: 2025/6/27, "abdominal roll around the bar": 20 (Rest on the ground after finishing each abdominal rotation on the bar.)(This is a gymnastics or calisthenics skill where a performer uses their abdominal strength to rotate their body around a horizontal bar (like a pull-up bar or high bar).)
2025/6/17, Tuesday: {"running": 5km}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 100}
6/17 6:17-6:40: run 5km in 22:50, Average Pace: 4:34/km
6/17 6:40-9:13: (A.1.1 Preprocessing), (A.1.2 Initial Analysis Plan Generation), ... (A.1.4 Re-evaluating the Analysis Plan)
6/17 9:13-10:58: A.2 CellBench
6/17 16:10-16:50: {"pull ups + Parallel Bar Dips": 200}
6/17 19:10-22:44: study the source code https://github.com/zou-group/CellVoyager, try to figure out how to run it
2025/6/18, Wednesday: {"running": rainy}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 100}
6/18 7:19-22:20: study the source code https://github.com/zou-group/CellVoyager,
2025/6/19, Thursday: {"running": 5km}, {"pull ups + Parallel Bar Dips": 200}
6/19 6:04-6:30: run 5km in 25:08, Average Pace: 5:01/km
6/19 7:20-19:20: study "class AnalysisAgent" (https://github.com/zou-group/CellVoyager)
2025/6/20, Friday: {"running": 5km}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 200}
6/20 6:19-6:52: run 5km in 32:24, Average Pace: 6:28/km
6/20 7:58-14:20: study "class AnalysisAgent" (https://github.com/zou-group/CellVoyager)
6/20 14:30-15:40 : Participate in the online public welfare seminar—"Observations and Reflections on the Application of AI in Clinical Drug Development"
6/20 15:40-22:00 : study "class AnalysisAgent", DeepResearch_Analyses.txt (https://github.com/zou-group/CellVoyager)
2025/6/21, Saturday: {"push ups + Mountain Climbers": 300}
9:46-12:00: study "class AnalysisAgent", DeepResearch_Analyses.txt (https://github.com/zou-group/CellVoyager)
2025/6/22, Sunday: {"running": 5km}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 300}
6:42-7:10: run 5.25km in 28:39, Average Pace: 5:27/km
8:00-10:45: DeepResearch_Analyses.txt (https://github.com/zou-group/CellVoyager)
2025/6/22: complete the whole paper and part of its source code: [CellVoyager: AI CompBio Agent Generates New Insights by Autonomously Analyzing Biological Data](https://www.biorxiv.org/content/10.1101/2025.06.03.657517v1.full.pdf) To fully understand the source code, I need to dive deeper into key tools like Scanpy and scVI. For now, I’ve decided to pause my study of this paper (which I’ll consider completed) and return to my work on AlphaFold 3.
6/22 12:16-19:30: 3.3 MSA Module (AlphaFold 3, https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-024-07487-w/MediaObjects/41586_2024_7487_MOESM1_ESM.pdf)
6/22 19:30-21:10: study the pytorch implementation of those algorithms in "3.3 MSA Module" (https://github.com/bytedance/Protenix)
2025/6/23, Monday: {"running": 5km}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 300}, {"Cartwheel Count": 22}
6/23 6:18-6:42: run 5km in 22:55, Average Pace: 4:35/km
6/23 8:02-18:00: study the pytorch implementation of those algorithms in "3.3 MSA Module" (https://github.com/bytedance/Protenix), I am a little confused by the implementation of "trunc_normal_init_"(I get it now, this is actually very simple.)
2025/6/24, Tuesday: {"running": rainy}, {"pull ups + Parallel Bar Dips": 0}, {"push ups + Mountain Climbers": 300}, {"Cartwheel Count": 0}
6/24 6:59-16:00: study the pytorch implementation of those algorithms in "3.3 MSA Module" (https://github.com/bytedance/Protenix), study "LinearNoBias"
2025/6/25, Wednesday: {"running": 2km}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 200}, {"Cartwheel Count": 0}
6/25 8:00-20:20: study the pytorch implementation of "Algorithm 1 Main Inference Loop" (https://github.com/bytedance/Protenix)
2025/6/26, Thursday: {"running": 2km}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 300}, {"Cartwheel Count": 20}, {"abdominal roll around the bar": 6}
6/26 9:54-20:00: study the pytorch implementation of "Algorithm 1 Main Inference Loop" (https://github.com/bytedance/Protenix)
2025/6/27, Friday: {"running": 5km}, {"pull ups + Parallel Bar Dips": 200}, {"push ups + Mountain Climbers": 0}, {"Cartwheel Count": 0}, {"abdominal roll around the bar": 20(I feel a bit dizzy.)}
6/27 6:54-7:18: run 5km in 23:12, Average Pace: 4:38/km
6/27 8:02-: study the pytorch implementation of "Algorithm 1 Main Inference Loop" and all called algorithms (https://github.com/bytedance/Protenix)
TODO: study [Association between resolved hepatitis B virus infection and depression in American adults : a cross-sectional study](https://www.nature.com/articles/s41598-025-99864-2)
2025/6/11 14:20- 6/22 10:45: CellVoyager: AI CompBio Agent Generates New Insights by Autonomously Analyzing Biological Data (Study of the paper's codebase is pending completion. I need to study the new tools Scanpy, scVI, etc)
0. Run 10km in 40 minutes, run a half marathon in 1 hour and 25 minutes, do 500 push-ups in a row, do 150 pull-ups in a row
0. Run 10km in 50 minutes, run a half marathon in 1 hour and 45 minutes, do 100 push-ups in a row, do 50 pull-ups in a row
https://github.com/ArcInstitute/state (virtual cell model ???)
study the latest work: https://x.com/FutureHouseSF
To conquer the universe, I need a physique as powerful as Goku's, along with his unyielding spirit and relentless determination.
人生如同白驹过隙，转瞬即逝，你所取得的一切成就荣耀,你所经历的一切失败,痛苦,磨难, 在你死后都将随风消散.在宇宙面前,你又算是什么? 亿万年之后, 谁又还记得谁 ? 既然如此,何不痛痛快快活一场, 轰轰烈烈干一番事业, 不枉此生, 也就足够了
Life is as fleeting as a white steed’s shadow—gone in the blink of an eye. All the achievements and honors you’ve earned, all the failures, pain, and hardships you’ve endured, will vanish like dust in the wind after your death. In the face of the universe, what are you? Billions of years later, who will still remember whom? Since that’s the case, why not live boldly, pursue great endeavors passionately, and make this life truly worthwhile? That alone is enough.
Become the first human to set foot on Mars and immortalize your name among the greatest explorers of all time.
Remember, a university's prestige and academic excellence are largely built and proven by the hard work and accomplishments of its students.
Set lofty aspirations, uphold great virtue, cultivate great talent, shoulder great responsibilities.