Mendelian randomization with GWAS summary data

A package for performing Mendelian randomization using GWAS summary data. It uses the IEU OpenGWAS database to obtain data automatically, and a wide range of methods to run the analysis.

January 2020 major update

We have made substantial changes to the package, database and reference panels. For full details of the changes, please visit https://mrcieu.github.io/TwoSampleMR/articles/gwas2020.html

Installation

Users running Windows and macOS, to install the latest version of TwoSampleMR please install from our MRC IEU r-universe

install.packages("TwoSampleMR", repos = c("https://mrcieu.r-universe.dev", "https://cloud.r-project.org"))

Users running Linux or WebR please see the following instructions.

To update the package run the same command again.

Installing from source

install.packages("remotes")
remotes::install_github("MRCIEU/TwoSampleMR")

To update the package just run the remotes::install_github("MRCIEU/TwoSampleMR") command again.

Docker

A multi-platform docker image containing R with the TwoSampleMR package pre-installed (for both x86_64 and ARM computers) is available here: https://hub.docker.com/r/mrcieu/twosamplemr

Documentation

Full documentation available here: https://mrcieu.github.io/TwoSampleMR/