Somatic mutations can be used for cell lineage tree reconstruction. Util now, several hypermutation system has been adpoted, and a ideal mutation system should be division-coupled, which at the same time wiil cause some problems. Cause semi-conservative DNA replication, division-coupled mutations are heterogeneous. It means that only one descendant cell inherits the new mutations from the mutated chain, while the other descendance remain unchanged.
Current phylogenetic tree methods are developed for long term evolution, in which the mutation space is far greater than the number of leaf, and evolution time is long enough for the internal nodes to dropout. In cell genealogy tree, the number of cell are tremendous, and the mutation accumulate in semi-conservative way.
semi-conservative genealogy aware algorithm (on the right)