-
Notifications
You must be signed in to change notification settings - Fork 1
/
Copy pathreport.html
13588 lines (11249 loc) · 954 KB
/
report.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01//EN">
<html>
<head>
<title>Promethease report for Zachary Collier's genome</title>
<meta http-equiv="Content-Type" content="text/html;charset=utf-8" >
<style type="text/css">
body {
font-family: arial, helvetica, sans-serif;
color: black;
}
button {
border: 1px solid #000000;
padding: 0px;
font-size: 4px;
margin-left: 1px;
}
button:hover {
cursor: pointer;
color: #ffffff;
}
#navmenu {
background-color: #F0F0F0;
position:fixed;
right:5px;
top:5px;
border:1px solid black;
z-index:2;
}
#navbox {
border:1px solid black;
padding-left: 170px;
float: right;
clear: none;
padding: 0px;
min-width: 50%;
max-width: 69%;
}
#treeDiv1 {
max-height:300px;
overflow: auto;
background-color: #F0F0F0;
float:left;
right:5px;
top:5px;
border:1px solid black;
clear: none;
min-width: 20%;
max-width: 30%;
padding: 0px;
}
#expandcontractdiv {
border:1px dotted #dedede;
background-color:#EBE4F2;
margin:0 0 .5em 0;
padding:0.4em;
}
.majorsection {
float:left;
width:95%;
border:1px solid black;
clear:both;
margin: 5px 0px;
padding: 0px 10px;
}
.sectiontext {
clear:both;
font-size: x-large;
}
.boxresult {
width: inherit;
margin: 10px auto;
border: 2px solid grey;
}
.boxgoodresult {
width: inherit;
margin: 10px auto;
border: 2px solid #80FF90;
}
.boxbadresult {
width: inherit;
margin: 10px auto;
border: 2px solid #FF8080;
}
.boxresultcol1 {
background-color: #FFFFFF;
float: left;
width: 190px;
margin: 0;
word-wrap: break-word;
}
.boxresultcol2 {
margin-left: 190px;
}
.boxlink {
float:left;
width:130px;
}
.boxfreq {
float:left;
width:170px;
clear:both;
}
.boxmag {
float:left;
width:170px;
clear:both;
}
.boxrep {
float:left;
width:170px;
clear:both;
}
.boxeffect {
float:left;
}
.gsboxeffect {
float:left;
clear: none;
}
.gsboxsummary {
float:left;
clear: none;
font-weight: bold;
}
.boxshow {
float:left;
width:100px;
}
.rstext {
float:left;
clear: left;
background-color: #D0D0FF;
}
.diseasebutton {
margin-left: 20px;
float:left;
clear: both;
}
.member-Topic {
margin-left: 40px;
border:1px solid black;
clear: both;
}
.member-is-a-medical-condition {
margin-left: 40px;
border:1px solid black;
clear: both;
}
.member-is-a-medicine {
margin-left: 40px;
border:1px solid black;
clear: both;
}
.adiseasebox {
width: 90%;
float:left;
margin-left: 40px;
clear: both;
}
.diseaselink {
margin-left: 240px;
FONT-SIZE: 18pt;
}
.diseaseinfo {
margin-left: 650px;
}
.boxfooter {
clear: both;
margin: 0;
border-top: 1px solid gray;
}
.majorboxfooter {
clear: both;
margin: 0;
border-top: 1px solid gray;
}
</style>
<script type="text/javascript">
function toggle(element) {
if (document.getElementById(element).style.display == "none") {
document.getElementById(element).style.display = "";
} else {
document.getElementById(element).style.display = "none";
}
}
function toggle2(element) {
if (document.getElementById(element).style.display == "none") {
document.getElementById(element).style.display = "";
document.getElementById('show-'+element).style.display = "none";
} else {
document.getElementById(element).style.display = "none";
document.getElementById('show-'+element).style.display = "";
}
}
function toggle3(name) {
var e=getElementsByClassName(name);
for ( var i=0; i < e.length; i++ ) {
if (e[i].style.display == "none") {
e[i].style.display = "";
document.getElementById('show-'+e[i].id).style.display = "none";
} else {
e[i].style.display = "none";
document.getElementById('show-'+e[i].id).style.display = "";
}
}
}
/*
Need to switch to this cleaner method
Crockford walkTheDOM http://javascript.crockford.com/hackday.ppt
function walkTheDOM(node, func) {
func(node);
node = node.firstChild;
while (node) {
walkTheDOM(node, func);
node = node.nextSibling;
}
}
function getElementsByClassName(className, node) {
var results = [];
walkTheDOM(node || document.body, function (node) {
var a, c = node.className, i;
if (c) {
a = c.split(' ');
for (i = 0; i < a.length; i += 1) {
if (a[i] === className) {
results.push(node);
break;
}
}
}
});
return results;
}
By now there is a more efficient method, but once upon a time this javascript served well enough
BEGIN:http://www.robertnyman.com
http://www.robertnyman.com/2008/05/27/the-ultimate-getelementsbyclassname-anno-2008/
cross platform 'getElementsByClassName'
Developed by Robert Nyman, http://www.robertnyman.com
Code/licensing: http://code.google.com/p/getelementsbyclassname/
*/
var getElementsByClassName = function (className, tag, elm){
if (document.getElementsByClassName) {
getElementsByClassName = function (className, tag, elm) {
elm = elm || document;
var elements = elm.getElementsByClassName(className),
nodeName = (tag)? new RegExp("\b" + tag + "\b", "i") : null,
returnElements = [],
current;
for(var i=0, il=elements.length; i<il; i+=1){
current = elements[i];
if(!nodeName || nodeName.test(current.nodeName)) {
returnElements.push(current);
}
}
return returnElements;
};
}
else if (document.evaluate) {
getElementsByClassName = function (className, tag, elm) {
tag = tag || "*";
elm = elm || document;
var classes = className.split(" "),
classesToCheck = "",
xhtmlNamespace = "http://www.w3.org/1999/xhtml",
namespaceResolver = (document.documentElement.namespaceURI === xhtmlNamespace)? xhtmlNamespace : null,
returnElements = [],
elements,
node;
for(var j=0, jl=classes.length; j<jl; j+=1){
classesToCheck += "[contains(concat(' ', @class, ' '), ' " + classes[j] + " ')]";
}
try {
elements = document.evaluate(".//" + tag + classesToCheck, elm, namespaceResolver, 0, null);
}
catch (e) {
elements = document.evaluate(".//" + tag + classesToCheck, elm, null, 0, null);
}
while ((node = elements.iterateNext())) {
returnElements.push(node);
}
return returnElements;
};
}
else {
getElementsByClassName = function (className, tag, elm) {
tag = tag || "*";
elm = elm || document;
var classes = className.split(" "),
classesToCheck = [],
elements = (tag === "*" && elm.all)? elm.all : elm.getElementsByTagName(tag),
current,
returnElements = [],
match;
for(var k=0, kl=classes.length; k<kl; k+=1){
classesToCheck.push(new RegExp("(^|\s)" + classes[k] + "(\s|$)"));
}
for(var l=0, ll=elements.length; l<ll; l+=1){
current = elements[l];
match = false;
for(var m=0, ml=classesToCheck.length; m<ml; m+=1){
match = classesToCheck[
m].test(current.className);
if (!match) {
break;
}
}
if (match) {
returnElements.push(current);
}
}
return returnElements;
};
}
return getElementsByClassName(className, tag, elm);
};
/* END:http://www.robertnyman.com */
function ShowEverything(){//we open all of them
var sections = new Array('diseasebox',
'member-is-a-Topic',
'member-is-a-medical-condition',
'member-is-a-medicine',
'rstext',
'boxrstext',
'boxshow',
'boxsection'
);
for ( var i_sect=0; i_sect < sections.length; i_sect++ ) {
var e=getElementsByClassName(sections[i_sect]);
for ( var i=0; i < e.length; i++ ) {
e[i].style.display = '';
}
}
}
</script>
<script type="text/javascript">//<![CDATA[
function IsDocumentAvailable(url) {
// http://stackoverflow.com/questions/5163690/check-if-htm-file-exists-on-local-disk-using-javascript
var fSuccess = false;
var client = null;
// XHR is supported by most browsers.
// IE 9 supports it (maybe IE8 and earlier) off webserver
// IE running pages off of disk disallows XHR unless security zones are set appropriately. Throws a security exception.
// Workaround is to use old ActiveX control on IE (especially for older versions of IE that don't support XHR)
// FireFox 4 supports XHR (and likely v3 as well) on web and from local disk
// Works on Chrome, but Chrome doesn't seem to allow XHR from local disk. (Throws a security exception) No workaround known.
try {
client = new XMLHttpRequest();
client.open("GET", url, false);
client.send();
}
catch (err) {
client = null;
}
// Try the ActiveX control if available
if (client === null) {
try {
client = new ActiveXObject("Microsoft.XMLHTTP");
client.open("GET", url, false);
client.send();
}
catch (err) {
// Giving up, nothing we can do
client = null;
}
}
fSuccess = Boolean(client && client.responseText);
return fSuccess;
}
// window.onload = function(e){
// var is_chrome = window.chrome;
// if (!is_chrome) {
// var found_subdir = IsDocumentAvailable("promethease_data/ui2libs/promethease.tooltip.css");
// if (!found_subdir) {
// alert("Error. It looks like you may have gone into the .zip file, without actually unzipping it.\n\nAs a result I cannot link to your subreports about Medicines, Medical Conditions, or UI2.\n\nYou need to really unzip the file for the full report to work.\n\nMore information at\nhttp://snpedia.com/index.php/Unzipping");
// }
// }
// }
//]]></script>
</head>
<body><p>
<a name='top'></a>
<div id='header'>
<h1><a href='http://www.promethease.com'>Promethease</a> Report</h1>
<h2>Version: 0.1.161</h2>
<h2>Generated: 2014-04-04 22:29</h2>
<h3>Infile: Zachary Collier's genome</h3><h3>Reference Population CEU</h3>
<h3>17124 genotypes annotated</h3>
</div>
<div id='navmenu'>
<h3><a href='http://www.snpedia.com/index.php?title=Promethease/results'>Help</a> interpreting your results.</h3>
<a href="javascript:ShowEverything()">Show Everything</a>
</div>
<div class="majorsection"><a href="promethease_data/report_ui2.html">UI version 2</a> interactive report</div><div class="majorsection">
<div class='sectiontext'>Good news</div>
<div class='boxshow' id="show-goodNews" style="display: inline;"><a href="javascript:toggle2('goodNews')">...more...</a></div>
<div class="boxsection" id="goodNews" style="display: none;"><a href="javascript:toggle2('goodNews')">(hide)</a>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs1800497'>rs1800497</a><a href='http://www.snpedia.com/index.php/rs1800497(C;C)'>(C;C)</a></div>
<div class='boxmag'>Magnitude: 3<br/>Frequency: <span style='background-color: #FFEBEB;'>66.4%</span><br/>Repute:Good<br/>References:94<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Normal (A2/A2): Better avoidance of errors. Normal OCD risk, normal Tardive Diskinesia risk, lower ADHD risk. Less Alcohol dependence. Higher risk of Postoperative Nausea. Lower obesity. Bupropion is effective. This DRD2 TaqIA A2/A2 version causes a normal amount of Dopamine Receptors. Learns from mistakes more easily. Men may have a higher risk of Obsessive Compulsive Disorder but lower risk of ADHD. Women have higher Persistence. Higher risk of Tardive Diskinesia when taking dopamine receptor antagonists. Lower risk of alcoholism and smoking addiction. Faster recovery from traumatic brain injury. 1.6x risk of early postoperative nausea within 6 hours of surgery. Bupropion (Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, Zyban, Voxra) works to quit smoking. Lower obesity due to incr...</div>
<div class='boxshow' id="show-sec-0.00210605335111" style="display: inline;"><a href="javascript:toggle2('sec-0.00210605335111')">...more...</a></div>
<div class='boxrstext' id="sec-0.00210605335111" style="display: none;"><a href="javascript:toggle2('sec-0.00210605335111')">(hide)</a>
<div class='rstext'>rs1800497, a SNP also known as the TaqIA (or Taq1A) polymorphism of the dopamine D2 receptor DRD2 gene (even though it is actually located over 10,000bp downstream of the gene), gives rise to the DRD2*A1 allele. This allele (rs1800497(T)) is associated with a reduced number of dopamine binding sites in the brain , and has been postulated to play a role in alcoholism, smoking, and certain neuropsychiatric disorders. The reduced number of dopamine binding sites may play a role in nicotine addiction by causing an 'understimulated' state that can be relieved by smoking (and/or use of other drugs). A wide variety of reports have been published over more than ten years either linking rs1800497 to aspects of nicotine use and smoking cessation success, or finding no such association. A meta-analys...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs6046'>rs6046</a><a href='http://www.snpedia.com/index.php/rs6046(T;T)'>(T;T)</a></div>
<div class='boxmag'>Magnitude: 2.8<br/>Frequency: <span style='background-color: #FF8181;'>2.8%</span><br/>Repute:Good<br/>References:20<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>better blood pressure, lower risk of myocardial infarction</div>
<div class='boxshow' id="show-sec-0.445387194055" style="display: inline;"><a href="javascript:toggle2('sec-0.445387194055')">...more...</a></div>
<div class='boxrstext' id="sec-0.445387194055" style="display: none;"><a href="javascript:toggle2('sec-0.445387194055')">(hide)</a>
<div class='rstext'>[OMIM:MYOCARDIAL INFARCTION, DECREASED SUSCEPTIBILITY TO]</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs4680'>rs4680</a><a href='http://www.snpedia.com/index.php/rs4680(A;A)'>(A;A)</a></div>
<div class='boxmag'>Magnitude: 2.5<br/>Frequency: <span style='background-color: #FFC3C3;'>24.8%</span><br/>Repute:Good<br/>References:223<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>(worrier) advantage in memory and attention tasks Little or no response to modafinil. You are more difficult to hypnotise. Placebo is more effective http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?ref=magazine&pagewanted=all</div>
<div class='boxshow' id="show-sec-0.721540032341" style="display: inline;"><a href="javascript:toggle2('sec-0.721540032341')">...more...</a></div>
<div class='boxrstext' id="sec-0.721540032341" style="display: none;"><a href="javascript:toggle2('sec-0.721540032341')">(hide)</a>
<div class='rstext'>rs4680 (Val158Met) is a well studied SNP in the COMT gene. 23andMe blog summarizes them as *rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions *rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis; summary at ) posits that people with Val alleles have increased COMT activity and lower prefrontal extracellular dopamine compar...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs189798'>rs189798</a><a href='http://www.snpedia.com/index.php/rs189798(T;T)'>(T;T)</a></div>
<div class='boxmag'>Magnitude: 2.1<br/>Frequency: <span style='background-color: #FF9A9A;'>7.1%</span><br/>Repute:Good<br/>References:1<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>decreased high myopia risk Less risk of high myopia (in French people). 34.2% of French people without high myopia have T here, but only 21.1% of controls do.(table)</div>
<div class='boxshow' id="show-sec-0.22876222127" style="display: inline;"><a href="javascript:toggle2('sec-0.22876222127')">...more...</a></div>
<div class='boxrstext' id="sec-0.22876222127" style="display: none;"><a href="javascript:toggle2('sec-0.22876222127')">(hide)</a>
<div class='rstext'></div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2511989'>rs2511989</a><a href='http://www.snpedia.com/index.php/rs2511989(A;G)'>(A;G)</a></div>
<div class='boxmag'>Magnitude: 2.1<br/>Frequency: <span style='background-color: #FFD6D6;'>40.7%</span><br/>Repute:Good<br/>References:10<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>0.63x decreased age-related macular degeneration risk</div>
<div class='boxshow' id="show-sec-0.945270695554" style="display: inline;"><a href="javascript:toggle2('sec-0.945270695554')">...more...</a></div>
<div class='boxrstext' id="sec-0.945270695554" style="display: none;"><a href="javascript:toggle2('sec-0.945270695554')">(hide)</a>
<div class='rstext'>news rs2511989 not associated with AMD rs2511989(A;A) had a protective effect against age related macular degeneration. Comparison of the rs2511989(A;G) genotype and the wild type (G;G) genotype yielded an odds ratio of 0.63 (CI: 0.47 to 0.84) for age-related macular degeneration. Comparison of rs2511989(A;A) homozygotes with (G;G) homozygotes resulted in an odds ratio of 0.44 (CI: 0.31 to 0.64). [PharmGKB:Curated A case-control study in a UK sample of 479 patients with age-related macular degeneration and 479 controls identified a highly significant association of this variant in intron six of the SERPING1 gene with age-related macular degeneration.]</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs3775291'>rs3775291</a><a href='http://www.snpedia.com/index.php/rs3775291(A;G)'>(A;G)</a></div>
<div class='boxmag'>Magnitude: 2.1<br/>Frequency: <span style='background-color: #FFDDDD;'>47.8%</span><br/>Repute:Good<br/>References:18<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>0.71x decreased risk for dry age related macular degeneration</div>
<div class='boxshow' id="show-sec-0.901427457611" style="display: inline;"><a href="javascript:toggle2('sec-0.901427457611')">...more...</a></div>
<div class='boxrstext' id="sec-0.901427457611" style="display: none;"><a href="javascript:toggle2('sec-0.901427457611')">(hide)</a>
<div class='rstext'>rs3775291 is a SNP in the TLR3 gene associated with an amino acid change in the corresponding protein. In the orientation as shown in dbSNP, the more common rs3775291(G) allele encodes a leucine while the rarer rs3775291(A) allele encodes a phenylalanine. rs3775291 has been associated with one form of age related macular degeneration (ARMD), specifically, the form known as 'dry' ARMD, also known as geographic atrophy. A study of 3 case-control groups of Americans of European descent, comprising about 900 ARMD patients in total, indicated that having one rs3775291(A) allele reduces the odds of having dry ARMD about 30%, and being a rs3775291(A;A) homozygote cuts your odds by more than half. Specifically, the odds ratio of having dry ARMD with one minor allele is 0.712 (CI: 0.50-1.0), and fo...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs1815739'>rs1815739</a><a href='http://www.snpedia.com/index.php/rs1815739(C;T)'>(C;T)</a></div>
<div class='boxmag'>Magnitude: 2.1<br/>Frequency: <span style='background-color: #FFE6E6;'>58.4%</span><br/>Repute:Good<br/>References:2<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Mix of muscle types. Likely sprinter. Normal for white people. One working and one defective copy of the gene for alpha-actinin-3 in fast-twitch muscle fibres. This genotype may indicate somewhat impaired muscles, however many sprinters and some endurance athletes have this.</div>
<div class='boxshow' id="show-sec-0.0305899830336" style="display: inline;"><a href="javascript:toggle2('sec-0.0305899830336')">...more...</a></div>
<div class='boxrstext' id="sec-0.0305899830336" style="display: none;"><a href="javascript:toggle2('sec-0.0305899830336')">(hide)</a>
<div class='rstext'>This SNP, in the ACTN3 gene, encodes a premature stop codon in a muscle protein called alpha-actinin-3. The polymorphism alters position 577 of the alpha-actinin-3 protein. In the (C;C) genotype is often called RR. The truncated (T;T) is often called XX. (T;T) is under-represented in elite strength athletes, consistent with previous reports indicating that alpha-actinin-3 deficiency appears to impair muscle performance. The most common nucleotide at this position, (C), encodes an arginine (amino acid code R), the alternative T allele encodes a stop codon (X). Hence, the SNP is referred to as R577X, with homozygotes being either RR or XX and heterozygotes being RX. XX individuals completely lack the expression of alpha-actinin-3. An earlier report studying a relatively small number of Austr...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs3129934'>rs3129934</a><a href='http://www.snpedia.com/index.php/rs3129934(C;C)'>(C;C)</a></div>
<div class='boxmag'>Magnitude: 2.1<br/>Frequency: <span style='background-color: #FFEBEB;'>66.1%</span><br/>Repute:Good<br/>References:7<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Normal lower risk of Multiple Sclerosis.</div>
<div class='boxshow' id="show-sec-0.0254458609935" style="display: inline;"><a href="javascript:toggle2('sec-0.0254458609935')">...more...</a></div>
<div class='boxrstext' id="sec-0.0254458609935" style="display: none;"><a href="javascript:toggle2('sec-0.0254458609935')">(hide)</a>
<div class='rstext'>rs3129934 is a SNP near the HLA-class II region that may be associated with several autoimmune diseases. In a study of two cohorts (Spanish and American multiple sclerosis patients, each numbering several hundred), rs3129934 was the SNP most associated with increased risk for multiple sclerosis. The odds ratio was 3.3 (CI: 2.3 - 4.9, p = 9 x 10e-11). Seven other SNPs were also identified in this study as associated with increased risk for MS. associated with type-1 diabetes. 1.6x risk of type-1 diabetes? 23andMe uses rs9273363 instead of rs3129934 in its reports on type 1 diabetes risk. This SNP was formerly used as a proxy for rs9272346, with this explanation: 'Note: the 2007 Wellcome Trust paper reported a strong association between type 1 diabetes and the SNP rs9272346. Our quality cont...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div id="gs101" class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxfreq'><div class='boxlink'><a href='http://www.snpedia.com/index.php/gs101'>gs101</a></div></div>
<div class='boxmag'>Magnitude: 2</div>
<div class='boxrep'>Repute: Good</div>
</div>
<div class='boxresultcol2'>
<div class='gsboxsummary'>probably able to digest milk</div>
<div class='gsboxeffect'>77% of Europeans with this are able to digest lactose and dairy products. People without this are more likely to experience lactose intolerance.</div>
</div>
<div class="boxfooter"></div>
</div>
<div id="gs269" class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxfreq'><div class='boxlink'><a href='http://www.snpedia.com/index.php/gs269'>gs269</a></div></div>
<div class='boxmag'>Magnitude: 2</div>
<div class='boxrep'>Repute: Good</div>
</div>
<div class='boxresultcol2'>
<div class='gsboxsummary'>APOE E2/E3</div>
<div class='gsboxeffect'>Slightly lower risk of Alzheimer's disease.</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2223841'>rs2223841</a><a href='http://www.snpedia.com/index.php/rs2223841(G;G)'>(G;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFA6A6;'>10.8%</span><br/>Repute:Good<br/>References:0<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>less likely to go bald less likely to experience baldness before age 40</div>
<div class='boxshow' id="show-sec-0.381204237688" style="display: inline;"><a href="javascript:toggle2('sec-0.381204237688')">...more...</a></div>
<div class='boxrstext' id="sec-0.381204237688" style="display: none;"><a href="javascript:toggle2('sec-0.381204237688')">(hide)</a>
<div class='rstext'>male-pattern baldness. Full text available. *G less likely to go bald before age 40 *A more likely to go bald before age 40</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2811712'>rs2811712</a><a href='http://www.snpedia.com/index.php/rs2811712(A;G)'>(A;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFABAB;'>12.4%</span><br/>Repute:Good<br/>References:1<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>1.5x less risk for physical impairment with age. This reduces the rate of physical problems with aging. It also reduces the risk of Cerebral Small Vessel Disease in the brain.</div>
<div class='boxshow' id="show-sec-0.216599397131" style="display: inline;"><a href="javascript:toggle2('sec-0.216599397131')">...more...</a></div>
<div class='boxrstext' id="sec-0.216599397131" style="display: none;"><a href="javascript:toggle2('sec-0.216599397131')">(hide)</a>
<div class='rstext'>rs2811712 is a SNP associated with physical function in older individuals, and thus indirectly associated with longevity. In a study ultimately totaling over 3,300 elderly Caucasian individuals, the less common rs2811712(G) allele was associated with reduced physical impairment. Overall, severely limited physical function was present in 15.0% of the more common rs2811712(A;A) homozygotes, versus 7.0% of the rs2811712(G;G) homozygotes, yielding a per risk allele odds ratio of 1.48 (CI: 1.17-1.88, p=0.001). Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Consortium analysis of 7 candidate SNPs for ovarian cancer. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer r...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2707466'>rs2707466</a><a href='http://www.snpedia.com/index.php/rs2707466(A;A)'>(A;A)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFB5B5;'>16.8%</span><br/>Repute:Good<br/>References:1<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>stronger bones</div>
<div class='boxshow' id="show-sec-0.422116575583" style="display: inline;"><a href="javascript:toggle2('sec-0.422116575583')">...more...</a></div>
<div class='boxrstext' id="sec-0.422116575583" style="display: none;"><a href="javascript:toggle2('sec-0.422116575583')">(hide)</a>
<div class='rstext'></div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2908004'>rs2908004</a><a href='http://www.snpedia.com/index.php/rs2908004(T;T)'>(T;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFB5B5;'>16.9%</span><br/>Repute:Good<br/>References:1<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>stronger bones</div>
<div class='boxshow' id="show-sec-0.0290407875749" style="display: inline;"><a href="javascript:toggle2('sec-0.0290407875749')">...more...</a></div>
<div class='boxrstext' id="sec-0.0290407875749" style="display: none;"><a href="javascript:toggle2('sec-0.0290407875749')">(hide)</a>
<div class='rstext'></div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2305795'>rs2305795</a><a href='http://www.snpedia.com/index.php/rs2305795(G;G)'>(G;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFBCBC;'>20.4%</span><br/>Repute:Good<br/>References:1<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>0.75x risk of narcolepsy compared to (A;G) genotype</div>
<div class='boxshow' id="show-sec-0.221691666273" style="display: inline;"><a href="javascript:toggle2('sec-0.221691666273')">...more...</a></div>
<div class='boxrstext' id="sec-0.221691666273" style="display: none;"><a href="javascript:toggle2('sec-0.221691666273')">(hide)</a>
<div class='rstext'>Common variants in P2RY11 are associated with narcolepsy. Found that rs2305795 G allele appears to lower the risk of narcolepsy. This SNP is also in the intronal area of the EIF3G gene.</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs11614913'>rs11614913</a><a href='http://www.snpedia.com/index.php/rs11614913(T;T)'>(T;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFBFBF;'>22.1%</span><br/>Repute:Good<br/>References:42<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>decreased risk for colorectal cancer and lung cancer source</div>
<div class='boxshow' id="show-sec-0.437887593651" style="display: inline;"><a href="javascript:toggle2('sec-0.437887593651')">...more...</a></div>
<div class='boxrstext' id="sec-0.437887593651" style="display: none;"><a href="javascript:toggle2('sec-0.437887593651')">(hide)</a>
<div class='rstext'>miRNA sequences and non-small cell lung cancer rs11614913 SNP in hsa-mir-196a2 was associated with survival in individuals with NSCLC. Specifically, survival was significantly decreased in individuals who were homozygous CC at SNP rs11614913. microRNA 1,009 breast cancer cases and 1,093 controls in a population of Chinese women *rs11614913 in hsa-mir-196a2 T>C 1.23; 95% confidence interval [CI], 1.02-1.48 *rs3746444 in hsa-mir-499 A>G OR 1.25; 95% CI, 1.02-1.51 Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. Signatures of purifying and local positive selection in human miRNAs. MicroRNA polymorphisms: the future of pharmacogenomics...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs6277'>rs6277</a><a href='http://www.snpedia.com/index.php/rs6277(T;T)'>(T;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFC1C1;'>23.8%</span><br/>Repute:Good<br/>References:51<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>normal schizophrenia risk, learns NoGo faster According to 23andMe blog this genotype is better for a particular learning task.</div>
<div class='boxshow' id="show-sec-0.495812241382" style="display: inline;"><a href="javascript:toggle2('sec-0.495812241382')">...more...</a></div>
<div class='boxrstext' id="sec-0.495812241382" style="display: none;"><a href="javascript:toggle2('sec-0.495812241382')">(hide)</a>
<div class='rstext'>rs6277 (957C>T, Pro319Pro) is one of several SNPs in the dopamine receptor DRD2 gene. In a study of 300+ Russian patients with schizophrenia, the rs6277(C) allele was associated with higher risk. From a pooled meta-study (total of 4 other reports plus this one) the allelic odds ratio is 1.42 (CI: 1.26-1.61, p<0.00005), and the genotypic odds ratio for the (C;C) genotype was 1.6 (CI: 1.32-1.95, p<0.00005). Note that rs6275 and rs6277 are only 18bp apart, hence their very tight linkage (r<sup>2</sup>=1). gs278 reflects a gene-gene interaction between this SNP and a NR3A SNP, rs10989591, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory. C allele associated significantly (p = 0.0...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs6983267'>rs6983267</a><a href='http://www.snpedia.com/index.php/rs6983267(T;T)'>(T;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFC2C2;'>23.9%</span><br/>Repute:Good<br/>References:130<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>normal risk for cancers; aspirin reduces risk for colorectal cancer This genotype is not on its own associated with higher cancer risk. Additionally, aspirin has been reported to somewhat lower the risk for colorectal cancer in individuals of this genotype.</div>
<div class='boxshow' id="show-sec-0.233084450258" style="display: inline;"><a href="javascript:toggle2('sec-0.233084450258')">...more...</a></div>
<div class='boxrstext' id="sec-0.233084450258" style="display: none;"><a href="javascript:toggle2('sec-0.233084450258')">(hide)</a>
<div class='rstext'>rs6983267 is a SNP on chromosome 8q24, associated with increased risk for several cancers, particularly prostate cancer. In studies dividing the 8q24 region, this SNP falls in region 3. This SNP has also been reported to influence the cancer-risk-decreasing effect of aspirin. In a study of over 3,600 Caucasians with prostate cancer, rs6983267 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs6983267(G;G) and (G;T) risk genotypes yield an odds ratio for developing prostate cancer of 1.37 (CI: 1.18-1.59, p=3.4-10e-5) and may account for 22.2% of population attributable risk. The increased risk of developing prostate cancer associated with rs6983267 now appears to be independent of the risk associated with its close neig...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs10784502'>rs10784502</a><a href='http://www.snpedia.com/index.php/rs10784502(C;C)'>(C;C)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFC5C5;'>26.5%</span><br/>Repute:Good<br/>References:0<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>better intracranial volume?</div>
<div class='boxshow' id="show-sec-0.230866541541" style="display: inline;"><a href="javascript:toggle2('sec-0.230866541541')">...more...</a></div>
<div class='boxrstext' id="sec-0.230866541541" style="display: none;"><a href="javascript:toggle2('sec-0.230866541541')">(hide)</a>
<div class='rstext'>associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10−12) http://www.genomesunzipped.org/2012/04/another-iq-gene-new-methods-old-flaws.php (C;C) has higher cranial capacity (about 2 teaspoons) and over 2% higher IQ. (C;T) is half this positive effect.</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs7538876'>rs7538876</a><a href='http://www.snpedia.com/index.php/rs7538876(G;G)'>(G;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFCCCC;'>31.2%</span><br/>Repute:Good<br/>References:6<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>0.78x decreased Basal Cell Carcinoma risk. Reduced risk of this kind of skin cancer.</div>
<div class='boxshow' id="show-sec-0.218781037338" style="display: inline;"><a href="javascript:toggle2('sec-0.218781037338')">...more...</a></div>
<div class='boxrstext' id="sec-0.218781037338" style="display: none;"><a href="javascript:toggle2('sec-0.218781037338')">(hide)</a>
<div class='rstext'>2 SNPs located in different regions of chromosome 1 are likely to be associated with increased risk for basal cell carcinoma (BCC), the most common form of skin cancer. *each A at rs7538876 yields a 1.28x increased risk of developing BCC (p = 4.4 x 10e-12) *each G at rs801114 also yields a 1.28x increased odds of developing BCC (p = 5.9 x 10e-12) *2.68x increased risk of BCC for homozygous carriers of both SNPs This study was based on an analysis of ~2,000 Icelandic and Eastern European skin cancer patients (as well as a large number of controls). The authors estimate that approximately 1.6% of all individuals of European ancestry are homozygous for both risk alleles, and thus that percentage of the population is at 2.68x higher risk for BCC compared to individuals who are rs7538876(G;G) a...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs4950928'>rs4950928</a><a href='http://www.snpedia.com/index.php/rs4950928(C;G)'>(C;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFCECE;'>32.8%</span><br/>Repute:Good<br/>References:19<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Half the risk (maybe) of Asthma. One study found a 0.54x lower risk for Asthma for this allele.</div>
<div class='boxshow' id="show-sec-0.459603465738" style="display: inline;"><a href="javascript:toggle2('sec-0.459603465738')">...more...</a></div>
<div class='boxrstext' id="sec-0.459603465738" style="display: none;"><a href="javascript:toggle2('sec-0.459603465738')">(hide)</a>
<div class='rstext'>rs4950928 in CHI3L1 is likely to play roles in the predisposition to schizophrenia. An attempt to repeat the association between rs4950928 and risk for schizophrenia in an ethnically identical population (Japanese) as well as a new population (Han Chinese) failed to show any significant association. In contrast to previous studies, in this study of 6514 Danish adults the rs4950928(G) allele - rather than the (C) allele - was found to be associated with asthma. [PharmGKB:Non-Curated GWAS Results: Effect of Variation in CHI31 on Serum YKL-40 Level, Risk of Asthma, and Lung Function (Initial Sample Size: 632 individuals; Replication Sample Size: 206 children; Risk Allele: rs4950928-G). This variant is associated with YKL-40 levels.] [OMIM:CHITINASE 3-LIKE 1; CHI3L1] [GWAS:YKL-40 levels]</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs6700998'>rs6700998</a><a href='http://www.snpedia.com/index.php/rs6700998(G;G)'>(G;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFCECE;'>33.6%</span><br/>Repute:Good<br/>References:0<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>0.83x reduced risk of Atopic Dermatitis. This seems to be a proxy that 23andMe uses for the filaggrin gene variants that they can't measure directly.</div>
<div class='boxshow' id="show-sec-0.28978161459" style="display: inline;"><a href="javascript:toggle2('sec-0.28978161459')">...more...</a></div>
<div class='boxrstext' id="sec-0.28978161459" style="display: none;"><a href="javascript:toggle2('sec-0.28978161459')">(hide)</a>
<div class='rstext'>Atopic Dermatitis</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2395185'>rs2395185</a><a href='http://www.snpedia.com/index.php/rs2395185(G;G)'>(G;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFCFCF;'>33.9%</span><br/>Repute:Good<br/>References:16<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>1.33x increased risk of Ulcerative Colitis, but much lower Type 1 Diabetes risk. This raises the risk of Ulcerative Colitis (according to 23andMe), but also greatly lowers the risk of Type 1 Diabetes. It may also affect other autoimmune diseases.</div>
<div class='boxshow' id="show-sec-0.0214897052659" style="display: inline;"><a href="javascript:toggle2('sec-0.0214897052659')">...more...</a></div>
<div class='boxrstext' id="sec-0.0214897052659" style="display: none;"><a href="javascript:toggle2('sec-0.0214897052659')">(hide)</a>
<div class='rstext'>A genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry, concluded that this SNP and several others were associated with altered risk for the disease. [PharmGKB:Non-Curated GWAS results: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (Initial Sample Size: 1,022 cases, 2,503 controls; Replication Sample Size: 1,387 cases, 1,115 controls); (Region: 6p21.32; Reported Gene(s): BTNL2, HLA-DRA, HLA-DRB5, HLA-DRB1, HLA-DQA1, HLA-DQB1; Risk Allele: rs2395185-?); (p-value= 0.0000000000000001).This variant is associated with Ulcerative colitis.] [OMIM:?] [GWAS:Ulcerative colitis]</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs1544410'>rs1544410</a><a href='http://www.snpedia.com/index.php/rs1544410(G;G)'>(G;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD0D0;'>34.5%</span><br/>Repute:Good<br/>References:102<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Decreased risk of low bone mineral density disorders</div>
<div class='boxshow' id="show-sec-0.837577975663" style="display: inline;"><a href="javascript:toggle2('sec-0.837577975663')">...more...</a></div>
<div class='boxrstext' id="sec-0.837577975663" style="display: none;"><a href="javascript:toggle2('sec-0.837577975663')">(hide)</a>
<div class='rstext'>rs1544410, also known as the BsmI polymorphism, is a SNP in the Vitamin D receptor (VDR). Multiple studies examining bone mineral density (BMD) in women have associated the A allele with increased risk of low BMD , , & . Additionally, A meta-analysis of 26 studies estimated a decreased risk of osteoporosis associated with the G;G genotype with an odds ratio of 0.61, 95% CI, 0.40-0.92 . rs1544410 increases susceptibility to Shorter stature for carriers of the A allele [PharmGKB:Curated This variant is associated with etidronate response in Caucasian (Slovenian) postmenopausal women (24 patients), with bb genotype associated with lower increase in bone mineral density (BMD) after bisphosphonate treatments.]</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs9642880'>rs9642880</a><a href='http://www.snpedia.com/index.php/rs9642880(G;G)'>(G;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD1D1;'>35.4%</span><br/>Repute:Good<br/>References:13<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Slightly lower risk of Bladder Cancer.</div>
<div class='boxshow' id="show-sec-0.556454322652" style="display: inline;"><a href="javascript:toggle2('sec-0.556454322652')">...more...</a></div>
<div class='boxrstext' id="sec-0.556454322652" style="display: none;"><a href="javascript:toggle2('sec-0.556454322652')">(hide)</a>
<div class='rstext'>rs9642880 is a SNP located in chromosome region 8q24, a region that has been linked to prostate, breast, and colon cancer. A study ultimately totaling over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of rs9642880(T) were at 1.49x increased risk (allele-specific odds ratio = 1.22, p = 9 x 10e-12) for the disease. This SNP was not associated, however, with risk for prostate, breast, or colon cancer. Another study in Chinese populations found similar results in regard to bladder cancer. rs9642880(T;T) estimated risk of developing 1.49 times that of noncarriers. 1,803 urinary bladder cancer cases and 34,336 controls. No association with prostate, colorectal and breast cancers. In contrast to GSTM1 SNPs, the rs9642880(T...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs4149268'>rs4149268</a><a href='http://www.snpedia.com/index.php/rs4149268(A;G)'>(A;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD5D5;'>39.8%</span><br/>Repute:Good<br/>References:10<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>associated with higher HDL cholesterol</div>
<div class='boxshow' id="show-sec-0.642294362932" style="display: inline;"><a href="javascript:toggle2('sec-0.642294362932')">...more...</a></div>
<div class='boxrstext' id="sec-0.642294362932" style="display: none;"><a href="javascript:toggle2('sec-0.642294362932')">(hide)</a>
<div class='rstext'>G allele is associated with 0.82mg/dl increase in HDL cholesterol (good cholesterol). [GWAS:HDL cholesterol]</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs8085664'>rs8085664</a><a href='http://www.snpedia.com/index.php/rs8085664(A;C)'>(A;C)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD6D6;'>40.7%</span><br/>Repute:Good<br/>References:0<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>0.78x reduced risk of Male Pattern Baldness. Discovered by 23andWe based on customer surveys, and considered preliminary research.</div>
<div class='boxshow' id="show-sec-0.185906265895" style="display: inline;"><a href="javascript:toggle2('sec-0.185906265895')">...more...</a></div>
<div class='boxrstext' id="sec-0.185906265895" style="display: none;"><a href="javascript:toggle2('sec-0.185906265895')">(hide)</a>
<div class='rstext'>This is the 23andWe discovery: 'Male Pattern Baldness: Preliminary Research'. It affects appearance.</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2073711'>rs2073711</a><a href='http://www.snpedia.com/index.php/rs2073711(C;T)'>(C;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD6D6;'>40.7%</span><br/>Repute:Good<br/>References:2<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Back Pain: lower risk of Lumbar Disc Disease. This appears to reduce the risk of LDD, at least in Japanese people and women.</div>
<div class='boxshow' id="show-sec-0.992543412176" style="display: inline;"><a href="javascript:toggle2('sec-0.992543412176')">...more...</a></div>
<div class='boxrstext' id="sec-0.992543412176" style="display: none;"><a href="javascript:toggle2('sec-0.992543412176')">(hide)</a>
<div class='rstext'>The rs2073711 SNP (1184T→C ) is located in exon 8 of the cartilage intermediate layer protein gene (CILP). However, CILP gene is primarily known to be expressed abundantly in intervertebral discs, and was reported to have increased expression when degeneration occurs . For the rs2073711 SNP, the ancestral allele is T and the disease associated risk allele is C. A study of Asian patients with lumbar disc disease (LDD) implicates each copy of a (C) allele of SNP rs2073711 (as oriented with respect to dbSNP) as increasing risk about 1.6 fold. ==Background== Low back pain (LBP) is an enervating condition that affects 70-85% of all people during their lifetime . It can lead to decreased physical activity and quality of life, presenting considerable negative socioeconomic and health impacts on m...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs801114'>rs801114</a><a href='http://www.snpedia.com/index.php/rs801114(T;T)'>(T;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD7D7;'>42.0%</span><br/>Repute:Good<br/>References:6<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>0.78x decreased Basal Cell Carcinoma risk.</div>
<div class='boxshow' id="show-sec-0.859946528795" style="display: inline;"><a href="javascript:toggle2('sec-0.859946528795')">...more...</a></div>
<div class='boxrstext' id="sec-0.859946528795" style="display: none;"><a href="javascript:toggle2('sec-0.859946528795')">(hide)</a>
<div class='rstext'>2 SNPs located in different regions of chromosome 1 are likely to be associated with increased risk for basal cell carcinoma (BCC), the most common form of skin cancer. *each A at rs7538876 yields a 1.28x increased risk of developing BCC (p = 4.4 x 10e-12) *each G at rs801114 also yields a 1.28x increased odds of developing BCC (p = 5.9 x 10e-12) *2.68x increased risk of BCC for homozygous carriers of both SNPs This study was based on an analysis of ~2,000 Icelandic and Eastern European skin cancer patients (as well as a large number of controls). The authors estimate that approximately 1.6% of all individuals of European ancestry are homozygous for both risk alleles, and thus that percentage of the population is at 2.68x higher risk for BCC compared to individuals who are rs7538876(G;G) a...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs9340799'>rs9340799</a><a href='http://www.snpedia.com/index.php/rs9340799(A;G)'>(A;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD8D8;'>42.4%</span><br/>Repute:Good<br/>References:79<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Women have normal (lower) risk of Endometriosis, 0.75x lower risk of Endometrial Cancer, and normal (higher) risk of cognitive impairment. Men have zero risk, but can pass this on to their daughters. One normal and one rare version of Estrogen Receptor 1 (alpha).</div>
<div class='boxshow' id="show-sec-0.120889959806" style="display: inline;"><a href="javascript:toggle2('sec-0.120889959806')">...more...</a></div>
<div class='boxrstext' id="sec-0.120889959806" style="display: none;"><a href="javascript:toggle2('sec-0.120889959806')">(hide)</a>
<div class='rstext'>rs9340799 is a SNP in the estrogen alpha receptor ESR1 gene, and it is also known as the -351A>G variant. Among women, rs8179176, rs9340799, rs1256065, and rs1256030 were associated with likelihood of developing cognitive impairment with ageing. In men, rs728524, rs1255998, and rs1256030 were associated with cognitive impairment. A study of 6,200+ Dutch individuals did not replicate previously reported associations between this SNP (rs9340799) and risk of ischemic stroke. A study of 702 cases with invasive endometrial cancer concluded that the less common alleles of SNP rs9340799 lowered risk for the disease. The odds ratio was 0.75 (CI: 0.60-0.93) for (A;G) and 0.53 (CI: 0.37-0.77) for (G;G) compared to rs9340799(A;A) individuals. Endometriosis Uterine Fibroids [PharmGKB:Curated SNP i...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs17070145'>rs17070145</a><a href='http://www.snpedia.com/index.php/rs17070145(C;T)'>(C;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD8D8;'>42.5%</span><br/>Repute:Good<br/>References:11<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>increased memory performance</div>
<div class='boxshow' id="show-sec-0.33269518536" style="display: inline;"><a href="javascript:toggle2('sec-0.33269518536')">...more...</a></div>
<div class='boxrstext' id="sec-0.33269518536" style="display: none;"><a href="javascript:toggle2('sec-0.33269518536')">(hide)</a>
<div class='rstext'>In a Swiss cohort: 'Carriers of KIBRA rs17070145 T allele had 24% better free recall performance 5 min after word presentation (P = 0.000004) and 19% better free recall performance 24 hours after word presentation (P = 0.0008) than did noncarriers.' In a US cohort: 'T allele carriers had significantly better memory scores than non-carriers in the Buschke's Selective Reminding Test (SRT). Performance on another episodic memory task, the Rey Auditory Verbal Learning Test (AVLT), was also significantly different between allele groups.' In another Swiss cohort, with a visual episodic memory task: 'T allele carriers also performed significantly better than did noncarriers in this population.' 'Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activ...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs1799990'>rs1799990</a><a href='http://www.snpedia.com/index.php/rs1799990(A;G)'>(A;G)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFD8D8;'>42.5%</span><br/>Repute:Good<br/>References:17<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>Resistance to Prion Disease (PrP 129 Met/Val heterozygote) This genotype codes for Met/Val heterozygote at codon 129 in PrP, the Prion Protein. This is strongly protective against development of Prion disease, including sporadic and infectious Creutzfeldt-Jakob disease. Studies in Papua New Guinea showed that this genotype prevents transmission of kuru , a form of Prion disease transmitted by cannibalism. So eat as many brains as you want!</div>
<div class='boxshow' id="show-sec-0.721484407583" style="display: inline;"><a href="javascript:toggle2('sec-0.721484407583')">...more...</a></div>
<div class='boxrstext' id="sec-0.721484407583" style="display: none;"><a href="javascript:toggle2('sec-0.721484407583')">(hide)</a>
<div class='rstext'>rs1799990, also known as Met129Val or M129V, is a SNP in the prion protein PRNP gene. The more common rs1799990(A) allele encodes the Met (methionine). Historically, since 1991 this SNP has been associated with risk for sporadic Creutzfeldt-Jakob disease, with homozygotes of both types apparently at increased risk compared to heterozygotes. More recently, this SNP has been related to long-term memory with (A;A) and (A;G) individuals recalling 17% more words than (G;G) individuals at 24h following learning. A further study of 12 individuals of each of the 3 possible genotypes showed that at both 30 minutes and 24 hour time lags, correlations between retrieval-related brain activity and retrieval success were negative for (G;) homozygotes (the more activity, the worse retrieval success), whi...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs3764261'>rs3764261</a><a href='http://www.snpedia.com/index.php/rs3764261(G;T)'>(G;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFDADA;'>44.2%</span><br/>Repute:Good<br/>References:47<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>associated with higher HDL cholesterol</div>
<div class='boxshow' id="show-sec-0.711191769695" style="display: inline;"><a href="javascript:toggle2('sec-0.711191769695')">...more...</a></div>
<div class='boxrstext' id="sec-0.711191769695" style="display: none;"><a href="javascript:toggle2('sec-0.711191769695')">(hide)</a>
<div class='rstext'>T allele is associated with 3.47mg/dl increase in HDL cholesterol (good cholesterol). [PharmGKB:Non-Curated Phenotype: In a GWAS, this SNP was significantly associated with plasma concentrations of HDL-C and apolipoprotein A1. Study size: 6382. Study population/ethnicity: Caucasian women. Significance metric(s): HDL-C: p = 1.0 x 10 (-41);ApoA1: p = 1.1 x 10(-34). Type of association: CO; GN] [OMIM:?] [GWAS:HDL cholesterol]</div>
</div>
</div>
<div class="boxfooter"></div>
</div>
<div class='boxgoodresult'>
<div class='boxresultcol1'>
<div class='boxlink'><a href='http://www.snpedia.com/index.php/rs2802292'>rs2802292</a><a href='http://www.snpedia.com/index.php/rs2802292(G;T)'>(G;T)</a></div>
<div class='boxmag'>Magnitude: 2<br/>Frequency: <span style='background-color: #FFDBDB;'>45.3%</span><br/>Repute:Good<br/>References:8<br/></div>
</div>
<div class='boxresultcol2'>
<div class='boxeffect'>One copy of longevity gene. Slightly increased lifespan. This is a well known longevity gene, FOXO3, although only one of your copies is the good version. It seems to improve insulin sensitivity, and decrease oxidative stress, among other things.</div>
<div class='boxshow' id="show-sec-0.936440586799" style="display: inline;"><a href="javascript:toggle2('sec-0.936440586799')">...more...</a></div>
<div class='boxrstext' id="sec-0.936440586799" style="display: none;"><a href="javascript:toggle2('sec-0.936440586799')">(hide)</a>
<div class='rstext'>A study of 5 genes in 3,741 Japanese men, some of whom lived significantly longer than average (centarians), concluded that the FOXO3 gene (also known as FOXO3A) harbors several SNPs linked to longevity, including this SNP, rs2802292, as well as rs2764264 and rs13217795. The odds ratio for rs2802292(G;G) vs (T;T) carriers was 2.75 (p = 0.00009; adjusted p = 0.00135). It is not known yet if this correlation is specific to Japanese males. This is discussed extensively at geneticfuture as a longevity snp. *(T) shorter lifespan *(G) longer lifespan Quoted from the geneticfuture article: 'No-one should consider this association to be definitive until it's been replicated in independent cohorts. Secondly, the effects of this variant are likely to differ between groups. According to the HapMap da...</div>
</div>
</div>
<div class="boxfooter"></div>
</div>