diff --git a/packages/runtime-dom/__tests__/directives/vModel.spec.ts b/packages/runtime-dom/__tests__/directives/vModel.spec.ts
index 534e5dfe98e..969a637af95 100644
--- a/packages/runtime-dom/__tests__/directives/vModel.spec.ts
+++ b/packages/runtime-dom/__tests__/directives/vModel.spec.ts
@@ -1,5 +1,6 @@
 import {
   type VNode,
+  computed,
   defineComponent,
   h,
   nextTick,
@@ -1409,6 +1410,51 @@ describe('vModel', () => {
     expect(bar.selected).toEqual(true)
   })
 
+  it('multiple select (v-model has custom setter)', async () => {
+    const selected = ref([])
+
+    const multipleSelected = computed({
+      get() {
+        return selected.value
+      },
+      set(newVal) {
+        selected.value = newVal.slice(0, 1)
+      },
+    })
+    const setValue = (v: any) => {
+      multipleSelected.value = v
+    }
+    const component = defineComponent({
+      render() {
+        return [
+          withVModel(
+            h(
+              'select',
+              {
+                multiple: true,
+                'onUpdate:modelValue': setValue,
+              },
+              [h('option', { value: '1' }), h('option', { value: '2' })],
+            ),
+            multipleSelected.value,
+          ),
+        ]
+      },
+    })
+    render(h(component), root)
+
+    await nextTick()
+    const select = root.querySelector('select')
+    const [foo, bar] = root.querySelectorAll('option')
+    foo.selected = true
+    bar.selected = true
+    triggerEvent('change', select)
+    await nextTick()
+    expect(selected.value).toEqual(['1'])
+    expect(foo.selected).toEqual(true)
+    expect(bar.selected).toEqual(false)
+  })
+
   // #10503
   test('equal value with a leading 0 should trigger update.', async () => {
     const setNum = function (this: any, value: any) {
diff --git a/packages/runtime-dom/src/directives/vModel.ts b/packages/runtime-dom/src/directives/vModel.ts
index 5057e16d472..01357c85ee4 100644
--- a/packages/runtime-dom/src/directives/vModel.ts
+++ b/packages/runtime-dom/src/directives/vModel.ts
@@ -4,6 +4,7 @@ import {
   type ObjectDirective,
   type VNode,
   nextTick,
+  toRaw,
   warn,
 } from '@vue/runtime-core'
 import { addEventListener } from '../modules/events'
@@ -38,9 +39,15 @@ function onCompositionEnd(e: Event) {
 }
 
 const assignKey: unique symbol = Symbol('_assign')
+const assignValueKey: unique symbol = Symbol('_value')
+const assigningKey: unique symbol = Symbol('_assigning')
 
 type ModelDirective<T, Modifiers extends string = string> = ObjectDirective<
-  T & { [assignKey]: AssignerFn; _assigning?: boolean },
+  T & {
+    [assignKey]: AssignerFn
+    [assignValueKey]: any
+    [assigningKey]?: boolean
+  },
   any,
   Modifiers
 >
@@ -210,16 +217,15 @@ export const vModelSelect: ModelDirective<HTMLSelectElement, 'number'> = {
         .map((o: HTMLOptionElement) =>
           number ? looseToNumber(getValue(o)) : getValue(o),
         )
-      el[assignKey](
-        el.multiple
-          ? isSetModel
-            ? new Set(selectedVal)
-            : selectedVal
-          : selectedVal[0],
-      )
-      el._assigning = true
+      const value = (el[assignValueKey] = el.multiple
+        ? isSetModel
+          ? new Set(selectedVal)
+          : selectedVal
+        : selectedVal[0])
+      el[assignKey](value)
+      el[assigningKey] = true
       nextTick(() => {
-        el._assigning = false
+        el[assigningKey] = false
       })
     })
     el[assignKey] = getModelAssigner(vnode)
@@ -233,7 +239,7 @@ export const vModelSelect: ModelDirective<HTMLSelectElement, 'number'> = {
     el[assignKey] = getModelAssigner(vnode)
   },
   updated(el, { value }) {
-    if (!el._assigning) {
+    if (!el[assigningKey] || toRaw(value) !== el[assignValueKey]) {
       setSelected(el, value)
     }
   },