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performance issues with cluster-features-open-reference #40

@nbokulich

Description

@nbokulich

Bug Description
Runtimes seem to be very slow relative to closed and de-novo on the same datasets.

This is probably the intermediate steps in the pipeline. One good indicator is that the bulk of open does not appear to run in parallel with multiple threads are requested (suggesting that it is hanging on those steps).

References
the intermediate steps

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