Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

adding HLAscan as a new module #146

Open
chrstphdm opened this issue Nov 7, 2022 · 1 comment
Open

adding HLAscan as a new module #146

chrstphdm opened this issue Nov 7, 2022 · 1 comment
Labels
enhancement New feature or request

Comments

@chrstphdm
Copy link

chrstphdm commented Nov 7, 2022

Description of feature

Hello,

As described in #145, adding more typing tools could allow us (among other things) to set up a result combination algorithm. If you compare it to other, HLAscan do not offer the best results (according to this and this benchmark for exemple) but is easy to setup and dataset used should be updatable (from IMGT/HLA EMBL flat file and some awk magic powder).

Algorithm/tool short description

All HLA typing algorithms can be divided into two broad categories: methods that assemble small reads de novo into longer contigs, and methods that directly match reads to HLA reference sequences. HLAscan belongs to the second group. At least 4 fields resolution is expected for class I and II loci.

Original paper

https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-017-1671-3

Source code/binary

Source code is not available, only binaries : https://github.com/SyntekabioTools/HLAscan

Licence

HLAscan software is freely available for academic purposes and a license is required for commercial download and installation

@chrstphdm chrstphdm added the enhancement New feature or request label Nov 7, 2022
@apeltzer
Copy link
Member

apeltzer commented Nov 8, 2022

Similar issue (saw also the discussion on Slack): Licencing and only binaries available 👎🏻 Epitopeprediction had similar issues, where eventually some open source method provided better rersults than the proprietary closed source thing and we "kind of dropped" it there (mhcpan / netmhcpan).

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
enhancement New feature or request
Projects
None yet
Development

No branches or pull requests

2 participants