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Add associations to similarity calculations #98

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caufieldjh opened this issue Sep 11, 2023 · 3 comments
Open

Add associations to similarity calculations #98

caufieldjh opened this issue Sep 11, 2023 · 3 comments

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@caufieldjh
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Primarily for Exomizer use case.

Calculating IC (and other metrics) currently only considers the ontology itself and does not include associations. If chosen, associations should be included as well.
This may be done over PHENIO, as long as association tables (e.g., for HP) are provided.

@matentzn
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Yes, we have already started playing with this:

phenio.owl + hpoa (+ other ingests) -> phenio-plus.owl (this is non trivial as you need to invert some of the ingests as part of this process) -> phenio-plus.db -> phenotypic_profile

This should I think be deployed as part of any Monarch KG release.

@caufieldjh
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@matentzn Are you (or could you) store the phenio-plus.db in an accessible location?

@matentzn
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Lemme check

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