diff --git a/src/modules/EnvironmentVariables/EnvironmentVariables/EnvironmentVariablesXAML/Views/MainPage.xaml b/src/modules/EnvironmentVariables/EnvironmentVariables/EnvironmentVariablesXAML/Views/MainPage.xaml
index af137c9057e5..312929be4a58 100644
--- a/src/modules/EnvironmentVariables/EnvironmentVariables/EnvironmentVariablesXAML/Views/MainPage.xaml
+++ b/src/modules/EnvironmentVariables/EnvironmentVariables/EnvironmentVariablesXAML/Views/MainPage.xaml
@@ -24,10 +24,24 @@
             <DataTemplate x:Key="VariableTemplate" x:DataType="models:Variable">
                 <controls:SettingsCard
                     CommandParameter="{x:Bind (models:Variable)}"
-                    Header="{x:Bind Name, Mode=TwoWay}"
                     IsActionIconVisible="False"
                     IsClickEnabled="False"
                     Style="{StaticResource DefaultSettingsExpanderItemStyle}">
+                    <controls:SettingsCard.Header>
+                        <StackPanel Orientation="Horizontal">
+                            <TextBlock Text="{x:Bind Name, Mode=TwoWay}" />
+                            <FontIcon
+                                Margin="6,0,6,0"
+                                FontSize="16"
+                                Foreground="{ThemeResource AccentTextFillColorPrimaryBrush}"
+                                Glyph="&#xE930;"
+                                Visibility="{x:Bind IsAppliedFromProfile, Converter={StaticResource BoolToVisibilityConverter}}">
+                                <ToolTipService.ToolTip>
+                                    <TextBlock x:Uid="VariableIsAppliedByActiveProfileTooltip" TextWrapping="Wrap" />
+                                </ToolTipService.ToolTip>
+                            </FontIcon>
+                        </StackPanel>
+                    </controls:SettingsCard.Header>
                     <controls:SettingsCard.Description>
                         <StackPanel HorizontalAlignment="Left">
                             <ItemsControl
@@ -52,7 +66,6 @@
                                 Visibility="{x:Bind ShowAsList, Converter={StaticResource BoolToInvertedVisibilityConverter}}" />
                         </StackPanel>
                     </controls:SettingsCard.Description>
-
                     <Button
                         Content="{ui:FontIcon Glyph=&#xE712;}"
                         IsEnabled="{x:Bind IsEditable}"
diff --git a/src/modules/EnvironmentVariables/EnvironmentVariables/Models/Variable.cs b/src/modules/EnvironmentVariables/EnvironmentVariables/Models/Variable.cs
index bb93189124f7..029b66feb2f3 100644
--- a/src/modules/EnvironmentVariables/EnvironmentVariables/Models/Variable.cs
+++ b/src/modules/EnvironmentVariables/EnvironmentVariables/Models/Variable.cs
@@ -28,12 +28,17 @@ public partial class Variable : ObservableObject, IJsonOnDeserialized
         [ObservableProperty]
         private bool _applyToSystem;
 
+        [JsonIgnore]
+        [property: JsonIgnore]
+        [ObservableProperty]
+        private bool _isAppliedFromProfile; // Used to mark that a variable in a default set is applied by a profile. Used to disable editing / mark it in the UI.
+
         [JsonIgnore]
         public bool IsEditable
         {
             get
             {
-                return ParentType != VariablesSetType.System || App.GetService<IElevationHelper>().IsElevated;
+                return (ParentType != VariablesSetType.System || App.GetService<IElevationHelper>().IsElevated) && !IsAppliedFromProfile;
             }
         }
 
diff --git a/src/modules/EnvironmentVariables/EnvironmentVariables/Strings/en-us/Resources.resw b/src/modules/EnvironmentVariables/EnvironmentVariables/Strings/en-us/Resources.resw
index c11f224c49e4..7ad6654168ff 100644
--- a/src/modules/EnvironmentVariables/EnvironmentVariables/Strings/en-us/Resources.resw
+++ b/src/modules/EnvironmentVariables/EnvironmentVariables/Strings/en-us/Resources.resw
@@ -280,4 +280,7 @@
   <data name="StateProfileNotApplicableMsg" xml:space="preserve">
     <value>Variables or backup variables are invalid.</value>
   </data>
+  <data name="VariableIsAppliedByActiveProfileTooltip.Text" xml:space="preserve">
+    <value>This variable is written by the active profile</value>
+  </data>
 </root>
\ No newline at end of file
diff --git a/src/modules/EnvironmentVariables/EnvironmentVariables/ViewModels/MainViewModel.cs b/src/modules/EnvironmentVariables/EnvironmentVariables/ViewModels/MainViewModel.cs
index 428d3db517ec..8bc7b208dc5e 100644
--- a/src/modules/EnvironmentVariables/EnvironmentVariables/ViewModels/MainViewModel.cs
+++ b/src/modules/EnvironmentVariables/EnvironmentVariables/ViewModels/MainViewModel.cs
@@ -67,6 +67,16 @@ private void LoadDefaultVariables()
             foreach (var variable in UserDefaultSet.Variables)
             {
                 DefaultVariables.Variables.Add(variable);
+                if (AppliedProfile != null)
+                {
+                    if (AppliedProfile.Variables.Where(
+                        x => (x.Name.Equals(variable.Name, StringComparison.OrdinalIgnoreCase) && x.Values.Equals(variable.Values, StringComparison.OrdinalIgnoreCase))
+                            || variable.Name.Equals(EnvironmentVariablesHelper.GetBackupVariableName(x, AppliedProfile.Name), StringComparison.OrdinalIgnoreCase)).Any())
+                    {
+                        // If it's a user variable that's also in the profile or is a backup variable, mark it as applied from profile.
+                        variable.IsAppliedFromProfile = true;
+                    }
+                }
             }
 
             foreach (var variable in SystemDefaultSet.Variables)