From c6e813338f4f730f558b2e4e675e69b7ffc65c2c Mon Sep 17 00:00:00 2001 From: Julian Stamp Date: Thu, 1 Dec 2022 11:33:36 -0500 Subject: [PATCH] missed changes. (#94) --- DESCRIPTION | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/DESCRIPTION b/DESCRIPTION index 8f407f9..56eceaa 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -18,8 +18,8 @@ Description: Epistasis, commonly defined as the interaction between genetic loci between a given variant and all other variants. By searching for marginal epistatic effects, one can identify genetic variants that are involved in epistasis without the need to identify the exact partners with which the variants interact – thus, potentially alleviating much of the statistical and computational burden associated with - conventional explicit search based methods. Our proposed mvMAPIT builds upon this strategy by taking of correlation - structures between traits to improve the identification of variants involved in epistasis. We formulate mvMAPIT as a + conventional explicit search based methods. Our proposed mvMAPIT builds upon this strategy by taking advantage of + correlation structure between traits to improve the identification of variants involved in epistasis. We formulate mvMAPIT as a multivariate linear mixed model and develop a multi-trait variance component estimation algorithm for efficient parameter inference and P-value computation. Together with reasonable model approximations, our proposed approach is scalable to moderately sized GWA studies.