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ABC scores don't sum to 1 #248

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kamalobbad opened this issue Feb 6, 2025 · 1 comment
Closed

ABC scores don't sum to 1 #248

kamalobbad opened this issue Feb 6, 2025 · 1 comment

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@kamalobbad
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kamalobbad commented Feb 6, 2025

I ran the ABC pipeline and am looking at the EnhancerPredictionsAllPutative.tsv.gz file. I'm finding that, given a gene, the ABC scores of it's candidate enhancers don't sum to 1. In one case, the ABC score is near 4. I referenced some of the ABC scores on encode and they all seem to be normalized as expected.

Is this intended behavior?

@mayasheth
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Resolved via email -- removing self-promoters, ABC scores sum to <1

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