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Relative Abundance of Transcripts (RATs)

The rats package aims to identify genes that show a shift in the relative abundance of their transcript isoforms between two conditions (Differential Transcript Usage -- DTU). This is supplementary to identifying Differential Transcript Expression (DTE), which simply measures whether transcripts change in abundance, but does not compare them to their sibling isoforms within each gene. Situations that show DTU are a subset of those that show DTE. The figure below shows the relationship between DTU and DTE, as well as between them and differential gene expression (DGE):

RATs Tutorial

Up-to-date instructions on how to install and use the package can be found in the package vignette, here.