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HN-Larynx.html
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<html>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<title>CA larynx</title>
<link rel="stylesheet" type="text/css" href="view.css" media="all">
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<style>
table, th, td {
border: 1px solid silver;
border-collapse: collapse;
padding: 4px;
}
</style>
</head>
<body>
<img id="top" src="top.png" alt="">
<div id="form_container">
<div class="form_description">
<h2>
<a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Larynx_4.2.0.0.REL_CAPCP.pdf" target="_blank">
<div class="tooltip">
Cancers of the larynx
<span class="tooltiptext">click to access explanations in the original CAP template</span>
</div>
</a>
</h2>
</div>
<p>
Please also refer to <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Bmk_2.0.0.1.REL_CAPCP.pdf" target="_blank">H&N biomarker protocol (HeadNeckBiomarkers 2.0.0.1, Nov-2021)</a> for possible ancillary testings.
</p>
<form>
<!--
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Gross descriptions:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td>
<label class="description">- Procedure:</label>
</td>
<td>
<select class="element select large" ID="A01">
<option value=""></option>
<option value=" - Excision">Excision</option>
<option value=" - Endolaryngeal excision">Endolaryngeal excision</option>
<option value=" - Transoral laser excision (glottis)">Transoral laser excision (glottis)</option>
<option value=" - Supraglottic laryngectomy">Supraglottic laryngectomy</option>
<option value=" - Supracricoid laryngectomy">Supracricoid laryngectomy</option>
<option value=" - Vertical hemilaryngectomy (specify side):">Vertical hemilaryngectomy (specify side):</option>
<option value=" - Partial laryngectomy (specify type):">Partial laryngectomy (specify type):</option>
<option value=" - Total laryngectomy">Total laryngectomy</option>
<option value=" - Neck (lymph node) dissection (specify):">Neck (lymph node) dissection (specify):</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor site:</label>
</td>
<td>
<select class="element select large" ID="A02">
<option value=""></option>
<option value=" - Larynx, supraglottis">Larynx, supraglottis</option>
<option value=" - Larynx, supraglottis + epiglottis, lingual aspect">Larynx, supraglottis + epiglottis, lingual aspect</option>
<option value=" - Larynx, supraglottis + epiglottis, laryngeal aspect">Larynx, supraglottis + epiglottis, laryngeal aspect</option>
<option value=" - Larynx, supraglottis + aryepiglottic folds">Larynx, supraglottis + aryepiglottic folds</option>
<option value=" - Larynx, supraglottis + arytenoid(s)">Larynx, supraglottis + arytenoid(s)</option>
<option value=" - Larynx, supraglottis + false vocal cord">Larynx, supraglottis + false vocal cord</option>
<option value=" - Larynx, supraglottis + ventricle">Larynx, supraglottis + ventricle</option>
<option value=" - Larynx, glottis">Larynx, glottis</option>
<option value=" - Larynx, glottis + true vocal cord">Larynx, glottis + true vocal cord</option>
<option value=" - Larynx, glottis + anterior commissure">Larynx, glottis + anterior commissure</option>
<option value=" - Larynx, glottis + posterior commissure">Larynx, glottis + posterior commissure</option>
<option value=" - Larynx, glottis + With subglottic extension">Larynx, glottis + With subglottic extension</option>
<option value=" - Larynx, subglottis">Larynx, subglottis</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Transglottic extension:</label>
</td>
<td>
<select class="element select large" ID="A03">
<option value=""></option>
<option value=" - Present">Present</option>
<option value=" - Not identified">Not identified</option>
</select>
</td>
</tr>
<tr>
<td valign="top">
<label class="description">- Tumor laterality:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A04" value=" - Right"><label >Right</label><br>
<input class="element checkbox" type="checkbox" id="A05" value=" - Left"><label >Left</label><br>
<input class="element checkbox" type="checkbox" id="A06" value=" - Midline"><label >Midline</label><br>
<input class="element checkbox" type="checkbox" id="A07" value=" - Not specified"><label >Cannot be determined (explain):</label><br>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor focality:</label>
</td>
<td>
<select class="element select large" ID="A08">
<option value=""></option>
<option value=" - Unifocal">Unifocal</option>
<option value=" - Multifocal">Multifocal</option>
<option value=" - Cannot be determined (explain):">Cannot be determined (explain):</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor size:</label>
</td>
<td>
<select class="element select large" ID="A09">
<option value=""></option>
<option value=" - Greatest dimension (mm): ">Greatest dimension (mm): </option>
<option value=" - All dimensions (mm x mm x mm): ">All dimensions (mm x mm x mm):</option>
<option value=" - Cannot be determined (explain): ">Cannot be determined (explain):</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
-->
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Microscopic descriptions:</label></legend>
<p>
<label class="description">- Tumor histology and immunohistochemical studies: </label>
<textarea ID="A10" class="element textarea medium"></textarea>
</p>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Larynx_4.2.0.0.REL_CAPCP.pdf#page=17" target="_blank">SCC and variants (WHO 5e)</a> :</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A11" value=" - Squamous cell carcinoma, conventional (keratinizing)"><label class="choice">Squamous cell carcinoma, conventional (keratinizing)</label>
<input class="element checkbox" type="checkbox" id="A12" value=" - Squamous cell carcinoma, nonkeratinizing"><label class="choice">Squamous cell carcinoma, nonkeratinizing</label>
<input class="element checkbox" type="checkbox" id="A14" value=" - Adenosquamous carcinoma"><label class="choice">Adenosquamous carcinoma</label>
<input class="element checkbox" type="checkbox" id="A15" value=" - Basaloid squamous cell carcinoma"><label class="choice">Basaloid squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A16" value=" - Papillary squamous cell carcinoma"><label class="choice">Papillary squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A17" value=" - Spindle cell squamous cell carcinoma"><label class="choice">Spindle cell squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A18" value=" - Verrucous squamous cell carcinoma"><label class="choice">Verrucous squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A19" value=" - Lymphoepithelial carcinoma (non-nasopharyngeal)"><label class="choice">Lymphoepithelial carcinoma (non-nasopharyngeal)</label>
</td>
</tr>
<tr>
<td valign="top">
<label class="description">- Minor salivary glands CA :</label>
</td>
<td>
<select class="element select large" ID="A20">
<option value=""></option>
<option value="Carcinoma ex pleomorphic adenoma, minimally invasive + malignant component">Carcinoma ex pleomorphic adenoma, minimally invasive + malignant component</option>
<option value="Carcinoma ex pleomorphic adenoma, invasive + malignant component">Carcinoma ex pleomorphic adenoma, invasive + malignant component</option>
<option value="Carcinoma ex pleomorphic adenoma, intracapsular (noninvasive) + malignant component">Carcinoma ex pleomorphic adenoma, intracapsular (noninvasive) + malignant component</option>
<option value="Carcinoma ex pleomorphic adenoma, extent cannot be determined + malignant component">Carcinoma ex pleomorphic adenoma, extent cannot be determined + malignant component</option>
<option value="Mucoepidermoid carcinoma, low grade">Mucoepidermoid carcinoma, low grade</option>
<option value="Mucoepidermoid carcinoma, intermediate grade">Mucoepidermoid carcinoma, intermediate grade</option>
<option value="Mucoepidermoid carcinoma, high grade">Mucoepidermoid carcinoma, high grade</option>
<option value="Adenoid cystic carcinoma, tubular pattern, specify percentage of solid component:">Adenoid cystic carcinoma, tubular pattern, specify percentage of solid component:</option>
<option value="Adenoid cystic carcinoma, cribriform pattern, specify percentage of solid component:">Adenoid cystic carcinoma, cribriform pattern, specify percentage of solid component:</option>
<option value="Adenoid cystic carcinoma, solid pattern, specify percentage of solid component:">Adenoid cystic carcinoma, solid pattern, specify percentage of solid component:</option>
<option value="Acinic cell carcinoma">Acinic cell carcinoma</option>
<option value="Secretory carcinoma">Secretory carcinoma</option>
<option value="Polymorphous adenocarcinoma, conventional">Polymorphous adenocarcinoma, conventional</option>
<option value="Polymorphous adenocarcinoma, cribriform subtype (% papillary and cribriform components)">Polymorphous adenocarcinoma, cribriform subtype (% papillary and cribriform components)</option>
<option value="Salivary duct carcinoma">Salivary duct carcinoma</option>
<option value="Epithelial-myoepithelial carcinoma">Epithelial-myoepithelial carcinoma</option>
<option value="Hyalinizing clear cell carcinoma">Hyalinizing clear cell carcinoma</option>
<option value="Microsecretory adenocarcinoma">Microsecretory adenocarcinoma</option>
<option value="Intraductal carcinoma (specify subtype):">Intraductal carcinoma (specify subtype):</option>
<option value="Basal cell adenocarcinoma">Basal cell adenocarcinoma</option>
<option value="Carcinosarcoma">Carcinosarcoma</option>
<option value="Mucinous adenocarcinoma, not otherwise specified">Mucinous adenocarcinoma, not otherwise specified</option>
<option value="Mucinous adenocarcinoma, intraductal papillary mucinous neoplasia subtype">Mucinous adenocarcinoma, intraductal papillary mucinous neoplasia subtype</option>
<option value="Mucinous adenocarcinoma, colloid / signet ring subtype">Mucinous adenocarcinoma, colloid / signet ring subtype</option>
<option value="Sclerosing microcystic adenocarcinoma">Sclerosing microcystic adenocarcinoma</option>
<option value="Lymphoepithelial carcinoma">Lymphoepithelial carcinoma</option>
<option value="Myoepithelial carcinoma">Myoepithelial carcinoma</option>
<option value="Sebaceous adenocarcinoma">Sebaceous adenocarcinoma</option>
<option value="Sialoblastoma">Sialoblastoma</option>
</select>
</td>
<tr>
<tr>
<td valign="top">
<label class="description">- Neuroendocrine carcinoma :</label>
</td>
<td>
<select class="element select large" ID="A21">
<option value=""></option>
<option value="Neuroendocrine tumor, grade 1"><label >Neuroendocrine tumor, grade 1</label></option>
<option value="Neuroendocrine tumor, grade 2"><label >Neuroendocrine tumor, grade 2</label></option>
<option value="Neuroendocrine tumor, grade 3"><label >Neuroendocrine tumor, grade 3</label></option>
<option value="Neuroendocrine carcinoma, small cell type"><label >Neuroendocrine carcinoma, small cell type</label></option>
<option value="Neuroendocrine carcinoma, large cell type"><label >Neuroendocrine carcinoma, large cell type</label></option>
<option value="Combined (or composite) neuroendocrine carcinoma with (specify types):"><label >Combined (or composite) neuroendocrine carcinoma with (specify types):</label></option>
</select>
</td>
<tr>
<tr>
<td valign="top">
<label class="description">- Other histologic type :</label>
</td>
<td>
<select class="element select large" ID="A22">
<option value=""></option>
<option value="Mucosal melanoma"><label >Mucosal melanoma</label></option>
<option value="Carcinoma, type cannot be determined"><label >Carcinoma, type cannot be determined</label></option>
<option value="Other histologic type not listed (specify):"><label >Other histologic type not listed (specify):</label></option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Larynx_4.2.0.0.REL_CAPCP.pdf#page=18" target="_blank">Histologic grade</a>:</label>
</td>
<td>
<select class="element select large" ID="A23">
<option value=""></option>
<option value="G1: Well differentiated">G1: Well differentiated</option>
<option value="G2: Moderately differentiated">G2: Moderately differentiated</option>
<option value="G3: Poorly differentiated">G3: Poorly differentiated</option>
<option value="GX: Cannot be assessed">GX: Cannot be assessed</option>
<option value="Other (specify):">Other (specify):</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Larynx_4.2.0.0.REL_CAPCP.pdf#page=19" target="_blank">Grade/Intrinsic biologic potential</a>:</label>
</td>
<td>
<select class="element select large" ID="A69">
<option value=""></option>
<option value="Not applicable">Not applicable</option>
<option value="Low">Low</option>
<option value="Intermediate">Intermediate</option>
<option value="High / High-grade transformation">High / High-grade transformation</option>
<option value="Cannot be assessed">Cannot be assessed</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + Tumor extension:</label>
</td>
<td>
<input type="text" class="element text large" ID="A24" size="45">
</td>
</tr>
<tr>
<td>
<label class="description">- Lymphatic and/or Vascular Invasion: </label>
</td>
<td>
<select class="element select large" ID="A25">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Larynx_4.2.0.0.REL_CAPCP.pdf#page=23" target="_blank">Perineural invasion</a>: </label>
</td>
<td>
<select class="element select large" ID="A26">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Present, intratumoral">Present, intratumoral</option>
<option value="Present, extratumoral">Present, extratumoral</option>
<option value="Present, intraneural, size of nerve">Present, intraneural, size of nerve</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description"><a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Larynx_4.1.1.0.REL_CAPCP.pdf#page=17" target="_blank">Surgical margins</a>: </label></legend>
<p>
<label class="description">- Surgical margins:</label>
<select class="element select medium" ID="A27">
<option value=""></option>
<option value="Cannot be assessed">Cannot be assessed</option>
<option value="Uninvolved by invasive carcinoma, specify location and closest distance:">Uninvolved by invasive carcinoma, specify location and closest distance:</option>
<option value="Uninvolved by high grade dysplasia/ in situ disease, specify location and closest distance:">Uninvolved by high grade dysplasia/ in situ disease, specify location and closest distance:</option>
<option value="Involved by invasive carcinoma, specify location:">Involved by invasive carcinoma, specify location:</option>
<option value="Involved by high grade dysplasia/ in situ disease, specify location:">Involved by high grade dysplasia/ in situ disease, specify location:</option>
</select>
</p>
<br>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Larynx_4.1.1.0.REL_CAPCP.pdf#page=18" target="_blank">Lymph nodes examination</a>: </label></legend>
<p>
<table border="1">
<col width="60%">
<tr>
<td>
<label class="description">- Number of regional lymph nodes examined:</label>
</td>
<td>
<input type="text" class="element text large" ID="A28" size="10">
</td>
</tr>
<tr>
<td>
<label class="description">- Number of lymph nodes involved:</label>
</td>
<td>
<input type="text" class="element text large" ID="A29" size="10">
</td>
</tr>
<tr>
<td>
<label class="description">- Extranodal extension (ENE) :</label>
</td>
<td>
<select class="element select large" ID="A30">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present, distance from capsule (mm): (> 2 mm, ENEma)">Present, distance from capsule (mm): (> 2 mm)</option>
<option value="Present, distance from capsule (mm): (< or = 2 mm, ENEmi)">Present, distance from capsule (mm): (< or = 2 mm)</option>
<option value="Present, distance from capsule (mm): (< 1 mm)">Present, distance from capsule (mm): (< 1 mm)</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest metastatic deposit (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A31" size="20">
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest lymph node involved (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A32" size="20">
</td>
</tr>
<tr>
<td>
<label class="description">- Laterality:</label>
</td>
<td>
<select class="element select large" ID="A33">
<option value=""></option>
<option value="Ipsilateral (including midline)">Ipsilateral (including midline)</option>
<option value="Contralateral">Contralateral</option>
<option value="Bilateral">Bilateral</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Distant Metastasis: </label></legend>
<input class="element checkbox" type="checkbox" id="A60" value=" - Not applicable"><label class="choice" >Not applicable</label>
<input class="element checkbox" type="checkbox" id="A61" value=" - Not identified"><label class="choice" >Not identified</label>
<input class="element checkbox" type="checkbox" id="A62" value=" - Non-regional lymph node(s) (specify):"><label class="choice" >Non-regional lymph node(s) (specify):</label>
<input class="element checkbox" type="checkbox" id="A63" value=" - Lung (specify):"><label class="choice" >Lung (specify):</label>
<input class="element checkbox" type="checkbox" id="A64" value=" - Liver (specify):"><label class="choice" >Liver (specify):</label>
<input class="element checkbox" type="checkbox" id="A65" value=" - Bone (specify):"><label class="choice" >Bone (specify):</label>
<input class="element checkbox" type="checkbox" id="A66" value=" - Brain (specify):"><label class="choice" >Brain (specify):</label>
<input class="element checkbox" type="checkbox" id="A67" value=" - Other (specify):"><label class="choice" >Other (specify):</label>
<input class="element checkbox" type="checkbox" id="A68" value=" - Cannot be determined: "><label class="choice" >Cannot be determined: </label>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Larynx_4.1.1.0.REL_CAPCP.pdf#page=21" target="_blank">Pathologic Stage Classification (AJCC 8e)</a>:</label></legend>
<p>
<table border="1">
<col width="50%">
<tr>
<td valign="top">
<label class="description">- TNM Descriptors:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A34" value=" m (multiple primary tumors) "><label class="choice">m (multiple primary tumors)</label>
<input class="element checkbox" type="checkbox" id="A35" value=" r (recurrent) "><label class="choice">r (recurrent)</label>
<input class="element checkbox" type="checkbox" id="A36" value=" y (post treatment) "><label class="choice">y (post treatment)</label>
</td>
</tr>
<tr>
<td>
<label class="description">- Primary tumor (pT) (for supraglottis):</label>
</td>
<td>
<select class="element select large" ID="A37">
<option value=""></option>
<option value=" - Primary tumor cannot be assessed">Primary tumor cannot be assessed</option>
<option value=" - Carcinoma in situ">Carcinoma in situ</option>
<option value=" - pT0: No evidence of primary tumor">pT0: No evidence of primary tumor</option>
<option value=" - pTis: Carcinoma in situ">pTis: Carcinoma in situ</option>
<option value=" - pT1: Tumor limited to one subsite of supraglottis with normal vocal cord mobility">pT1: Tumor limited to one subsite of supraglottis with normal vocal cord mobility"</option>
<option value=" - pT2: Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (eg, mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx">pT2: Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (eg, mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx</option>
<option value=" - pT3: Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage">pT3: Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage</option>
<option value=" - pT4: Moderately advanced or very advanced disease">pT4: Moderately advanced or very advanced local disease</option>
<option value=" - pT4a: Moderately advanced local disease. Tumor invades through the outer cortex thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, soft tissues of neck including deep extrinsic muscle of tongue, strap muscles, thyroid, or esophagus)">pT4a: Moderately advanced local disease. Tumor invades through the outer cortex thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, soft tissues of neck including deep extrinsic muscle of tongue, strap muscles, thyroid, or esophagus)</option>
<option value=" - pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures">pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Primary tumor (pT) (for glottis):</label>
</td>
<td>
<select class="element select large" ID="A38">
<option value=""></option>
<option value=" - Primary tumor cannot be assessed">Primary tumor cannot be assessed</option>
<option value=" - Carcinoma in situ">Carcinoma in situ</option>
<option value=" - pT0: No evidence of primary tumor">pT0: No evidence of primary tumor</option>
<option value=" - pTis: Carcinoma in situ">pTis: Carcinoma in situ</option>
<option value=" - pT1: Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility">pT1: Tumor limited to the vocal cord(s)(may involve anterior or posterior commissure) with normal mobility</option>
<option value=" - pT1a: Tumor limited to one vocal cord">pT1a: Tumor limited to one vocal cord</option>
<option value=" - pT1b: Tumor involves both vocal cords">pT1b: Tumor involves both vocal cords</option>
<option value=" - pT2: Tumor extends to supraglottis and/or subglottis and/or with impaired vocal cord mobility">pT2: Tumor extends to supraglottis and/or subglottis and/or with impaired vocal cord mobility</option>
<option value=" - pT3: Tumor limited to the larynx with vocal cord fixation and/or invasion of paraglottic space and/or inner cortex of the thyroid cartilage">pT3: Tumor limited to the larynx with vocal cord fixation and/or invasion of paraglottic space and/or inner cortex of the thyroid cartilage</option>
<option value=" - pT4: Moderately advanced or very advanced disease">pT4: Moderately advanced or very advanced local disease</option>
<option value=" - pT4a: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, cricoid cartilage, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus)">pT4a: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, cricoid cartilage, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus)</option>
<option value=" - pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures">pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Primary tumor (pT) (for subglottis):</label>
</td>
<td>
<select class="element select large" ID="A39">
<option value=""></option>
<option value=" - Primary tumor cannot be assessed">Primary tumor cannot be assessed</option>
<option value=" - Carcinoma in situ">Carcinoma in situ</option>
<option value=" - pT0: No evidence of primary tumor">pT0: No evidence of primary tumor</option>
<option value=" - pTis: Carcinoma in situ">pTis: Carcinoma in situ</option>
<option value=" - pT1: Tumor limited to subglottis">pT1: Tumor limited to subglottis</option>
<option value=" - pT2: Tumor extends to vocal cord(s) with normal or impaired mobility">pT2: Tumor extends to vocal cord(s) with normal or impaired mobility</option>
<option value=" - pT3: Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage">pT3: Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage</option>
<option value=" - pT4: Moderately advanced or very advanced disease">pT4: Moderately advanced or very advanced local disease</option>
<option value=" - pT4a: Moderately advanced local disease. Tumor invades through the outer cortex thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, soft tissues of neck including deep extrinsic muscle of tongue, strap muscles, thyroid, or esophagus)">pT4a: Moderately advanced local disease. Tumor invades through the outer cortex thyroid cartilage and/or invades tissues beyond the larynx (eg, trachea, soft tissues of neck including deep extrinsic muscle of tongue, strap muscles, thyroid, or esophagus)</option>
<option value=" - pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures">pT4b: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Regional lymph nodes (pN):</label>
</td>
<td>
<select class="element select large" ID="A40">
<option value=""></option>
<option value=" - pN not assigned (no nodes submitted or found)">pN not assigned (no nodes submitted or found)</option>
<option value=" - pN not assigned (cannot be determined based on available pathological information)">pN not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pN0: No regional lymph node metastasis">pN0: No regional lymph node metastasis</option>
<option value=" - pN1: Metastasis in a single ipsilateral lymph node, < or = 3 cm and ENE(-)">pN1: Metastasis in a single ipsilateral lymph node, < or = 3 cm and ENE(-)</option>
<option value=" - pN2a: Metastasis in single ipsilateral node < or = 3 cm and ENE(+)">pN2a: Metastasis in single ipsilateral node < or = 3 cm and ENE(+)</option>
<option value=" - pN2a: Metastasis in a single ipsilateral node > 3 cm but < or = 6 cm and ENE(-)">pN2a: Metastasis in a single ipsilateral node > 3 cm but < or = 6 cm and ENE(−)</option>
<option value=" - pN2b: Metastases in multiple ipsilateral nodes, < or = 6 cm and ENE(-)">pN2b: Metastases in multiple ipsilateral nodes, < or = 6 cm and ENE(−)</option>
<option value=" - pN2c: Metastases in bilateral or contralateral lymph node(s), < or = 6 cm and ENE(-)">pN2c: Metastases in bilateral or contralateral lymph node(s), < or = 6 cm and ENE(−)</option>
<option value=" - pN3a: Metastasis in a lymph node > 6 cm and ENE(−)">pN3a: Metastasis in a lymph node > 6 cm and ENE(−)</option>
<option value=" - pN3b: Metastasis in a single ipsilateral node > 3 cm and ENE(+)">pN3b: Metastasis in a single ipsilateral node > 3 cm and ENE(+)</option>
<option value=" - pN3b: Metastasis in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+)">pN3b: Metastasis in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+)</option>
<option value=" - pN3b: Metastasis in a single contralateral node of any size and ENE(+)">pN3b: Metastasis in a single contralateral node of any size and ENE(+)</option>
</select>
</td>
</tr>
</tr>
<td >
<label class="description">- Distant metastasis (pM):</label>
</td>
<td>
<select class="element select large" ID="A41">
<option value=""></option>
<option value=" - Not applicable - pM cannot be determined from the submitted specimen(s)">Not applicable - pM cannot be determined from the submitted specimen(s)</option>
<option value=" - pM1: Distant metastasis">pM1:Distant metastasis</option>
</select>
</td>
</tr>
<!--
<tr>
<td>
- Specify site(s), if known:
<input type="text" class="element text small" ID="A42" size="35">
</td>
</tr>
-->
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Pathologic Stage Classification (AJCC 8e) for mucosal melanoma:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description">- TNM Descriptors:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A43" value=" m (multiple primary tumors) "><label class="choice">m (multiple primary tumors)</label>
<input class="element checkbox" type="checkbox" id="A44" value=" r (recurrent) "><label class="choice">r (recurrent</label>
<input class="element checkbox" type="checkbox" id="A45" value=" y (post treatment) "><label class="choice" >y (post treatment)</label>
</td>
</tr>
<tr>
<td>
<label class="description">- Primary tumor (pT):</label>
</td>
<td>
<select class="element select large" ID="A46">
<option value=""></option>
<option value=" - pT3: Tumors limited to the mucosa and immediately underlying soft tissue, regardless of thickness or greatest dimension; for example, polypoid nasal disease, pigmented or nonpigmented lesions of the oral cavity, pharynx, or larynx">pT3: Tumors limited to the mucosa and immediately underlying soft tissue, regardless of thickness or greatest dimension; for example, polypoid nasal disease, pigmented or nonpigmented lesions of the oral cavity, pharynx, or larynx</option>
<option value=" - pT4: Moderately advanced or very advanced disease">pT4: Moderately advanced or very advanced disease</option>
<option value=" - pT4a: Moderately advanced disease: Tumor involving deep soft tissue, cartilage, bone, or overlying skin">pT4a: Moderately advanced disease: Tumor involving deep soft tissue, cartilage, bone, or overlying skin</option>
<option value=" - pT4b: Very advanced disease: Tumor involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures">pT4b: Very advanced disease. Tumor involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Regional lymph nodes (pN):</label>
</td>
<td>
<select class="element select large" ID="A47">
<option value=""></option>
<option value=" - pNX: Regional lymph nodes cannot be assessed">pNX: Regional lymph nodes cannot be assessed</option>
<option value=" - pN0: No regional lymph node metastasis">pN0: No regional lymph node metastasis</option>
<option value=" - pN1: Regional lymph node metastases present">pN1: Regional lymph node metastases present</option>
</select>
</td>
</tr>
<tr>
<td >
<label class="description">- Distant metastasis (pM):</label>
</td>
<td>
<select class="element select large" ID="A48">
<option value=""></option>
<option value=" - Not applicable - pM cannot be determined from the submitted specimen(s)">Not applicable - pM cannot be determined from the submitted specimen(s)</option>
<option value=" - pM1: Distant metastasis">pM1:Distant metastasis</option>
</select>
</td>
</tr>
<!--
<tr>
<td>
- Specify site(s), if known:
<input type="text" class="element text small" ID="A49" size="35">
</td>
</tr>
-->
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class=""> + Additional pathologic findings: </label></legend>
<p>
<input class="element checkbox" type="checkbox" id="A50" value=" - Dysplasia, low grade (includes hyperplasia, keratosis, and mild dysplasia)"><label class="choice"><a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Larynx_4.1.1.0.REL_CAPCP.pdf#page=23" target="_blank">Dysplasia, low grade (includes hyperplasia, keratosis, and mild dysplasia)</a></label>
<input class="element checkbox" type="checkbox" id="A51" value=" - Dysplasia, high grade (includes moderate to severe dysplasia, and carcinoma in situ)"><label class="choice"><a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Larynx_4.1.1.0.REL_CAPCP.pdf#page=23" target="_blank">Dysplasia, high grade (includes moderate to severe dysplasia, and carcinoma in situ)</a></label>
<input class="element checkbox" type="checkbox" id="A52" value=" - Squamous papilloma, solitary"><label class="choice">Sinonasal papilloma (specify type): </label>
<input class="element checkbox" type="checkbox" id="A53" value=" - Squamous papillomatosis"><label class="choice">Squamous papillomatosis</label>
<input class="element checkbox" type="checkbox" id="A54" value=" - Inflammation (specify type):"><label class="choice">Inflammation (specify type):</label>
<input class="element checkbox" type="checkbox" id="A55" value=" - Squamous metaplasia"><label class="choice">Squamous metaplasia</label>
<input class="element checkbox" type="checkbox" id="A56" value=" - Colonization, fungal"><label class="choice">Colonization, fungal</label>
<input class="element checkbox" type="checkbox" id="A57" value=" - Colonization, bacterial"><label class="choice">Colonization, bacterial</label>
</p>
<p>- Other (specify):
<input type="text" class="element text small" ID="A58" size="35">
</p>
<br>
</fieldset>
</p>