diff --git a/.changeset/mighty-worlds-smoke.md b/.changeset/mighty-worlds-smoke.md
new file mode 100644
index 00000000000..3ab3aa5e7c4
--- /dev/null
+++ b/.changeset/mighty-worlds-smoke.md
@@ -0,0 +1,7 @@
+---
+'@whatwg-node/node-fetch': patch
+'@whatwg-node/server': patch
+'@whatwg-node/fetch': patch
+---
+
+Fixes the `TypeError: bodyInit.stream is not a function` error thrown when `@whatwg-node/server` is used with `node:http2` and attempts the incoming HTTP/2 request to parse with `Request.json`, `Request.text`, `Request.formData`, or `Request.blob` methods.
diff --git a/packages/node-fetch/src/Body.ts b/packages/node-fetch/src/Body.ts
index 53d1a581bbf..cef8a55dc03 100644
--- a/packages/node-fetch/src/Body.ts
+++ b/packages/node-fetch/src/Body.ts
@@ -508,7 +508,7 @@ function isFormData(value: any): value is FormData {
 }
 
 function isBlob(value: any): value is Blob {
-  return value?.stream != null;
+  return value?.stream != null && typeof value.stream === 'function';
 }
 
 function isURLSearchParams(value: any): value is URLSearchParams {
diff --git a/packages/server/test/http2.spec.ts b/packages/server/test/http2.spec.ts
index ad472f655f5..e59bc0bf497 100644
--- a/packages/server/test/http2.spec.ts
+++ b/packages/server/test/http2.spec.ts
@@ -27,13 +27,22 @@ describeIf(!globalThis.Bun && !globalThis.Deno)('http2', () => {
 
   runTestsForEachFetchImpl((_, { createServerAdapter }) => {
     it('should support http2 and respond as expected', async () => {
-      let calledRequest: Request | undefined;
-      const handleRequest = jest.fn((_request: Request) => {
-        calledRequest = _request;
-        return new Response('Hey there!', {
-          status: 418,
-          headers: { 'x-is-this-http2': 'yes', 'content-type': 'text/plain;charset=UTF-8' },
-        });
+      const handleRequest = jest.fn(async (request: Request) => {
+        return Response.json(
+          {
+            body: await request.json(),
+            headers: Object.fromEntries(request.headers),
+            method: request.method,
+            url: request.url,
+          },
+          {
+            headers: {
+              'x-is-this-http2': 'yes',
+              'content-type': 'text/plain;charset=UTF-8',
+            },
+            status: 418,
+          },
+        );
       });
       const adapter = createServerAdapter(handleRequest);
 
@@ -49,11 +58,16 @@ describeIf(!globalThis.Bun && !globalThis.Deno)('http2', () => {
       const req = client.request({
         [constantsHttp2.HTTP2_HEADER_METHOD]: 'POST',
         [constantsHttp2.HTTP2_HEADER_PATH]: '/hi',
+        [constantsHttp2.HTTP2_HEADER_CONTENT_TYPE]: 'application/json',
       });
 
+      req.write(JSON.stringify({ hello: 'world' }));
+      req.end();
+
       const receivedNodeRequest = await new Promise<{
         headers: Record<string, string | string[] | undefined>;
         data: string;
+        status?: number | undefined;
       }>((resolve, reject) => {
         req.once(
           'response',
@@ -68,7 +82,8 @@ describeIf(!globalThis.Bun && !globalThis.Deno)('http2', () => {
             req.on('end', () => {
               resolve({
                 headers,
-                data,
+                data: JSON.parse(data),
+                status: headers[':status'],
               });
             });
           },
@@ -77,18 +92,25 @@ describeIf(!globalThis.Bun && !globalThis.Deno)('http2', () => {
       });
 
       expect(receivedNodeRequest).toMatchObject({
-        data: 'Hey there!',
+        data: {
+          body: {
+            hello: 'world',
+          },
+          method: 'POST',
+          url: expect.stringMatching(/^http:\/\/localhost:\d+\/hi$/),
+          headers: {
+            'content-type': 'application/json',
+          },
+        },
         headers: {
           ':status': 418,
           'content-type': 'text/plain;charset=UTF-8',
           'x-is-this-http2': 'yes',
         },
+        status: 418,
       });
 
       await new Promise<void>(resolve => req.end(resolve));
-
-      expect(calledRequest?.method).toBe('POST');
-      expect(calledRequest?.url).toMatch(/^http:\/\/localhost:\d+\/hi$/);
     });
   });
 });