diff --git a/packages/core/src/render3/util/global_utils.ts b/packages/core/src/render3/util/global_utils.ts
index e96704672b873f..cfb4aa05be4b70 100644
--- a/packages/core/src/render3/util/global_utils.ts
+++ b/packages/core/src/render3/util/global_utils.ts
@@ -71,8 +71,9 @@ export function publishDefaultGlobalUtils() {
   if (!_published) {
     _published = true;
 
-    if (typeof window !== 'undefined') {
-      // Only configure the injector profiler when running in the browser.
+    // Only configure the injector profiler when running in the browser and WeakRef is defined.
+    // In some G3 test WeakRef is undefined as they user older (unsupported) browsers to test.
+    if (typeof window !== 'undefined' && typeof WeakRef !== 'undefined') {
       setupFrameworkInjectorProfiler();
     }