Easy and simple mendelian randomization tool using GWAS summary statistics.
Simple Mendelian Randomization(Simple_MR)
THIS PROGRAM BUILD BY R 3.6 ver
Need R library :
MendelianRandomization : an R package for performing Mendelian randomization
analyses using summarized data. O Yavorska, S Burgess
MRPRESSO : Detection of widespread horizontal pleiotropy in causal relationships
inferred from Mendelian randomization between complex traits and diseases.
Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron D.
Nature Genetics volume 50, pages693–698(2018)
Require OPTIONS
| Option | Require | Discription |
|---|---|---|
| -h/ --help | optional | print this help message |
| -e/ --Exposure |
require | Exposure Summary statistics |
| -o/ --Outcome |
require | Outcome Summary statistics |
| -d/ --OutDIRPrefix |
require | Simple MR results out DIR Prefix, Make New Directory, Ansolute Pathway Optional OPTIONS for Exposure LD clumpling |
| -p --Presso |
optional | YES or NO defualt YES, Deletion Outlier use MRPRESSO |
| -P --plink |
optional | plink 1.9 program download by https://www.cog-genomics.org/plink2 |
| -b --bfile |
optional | plink input format: .bed .bim .fam prefix |
input summary statistic file format :
Any format usefull!
but file head include by SNP,BETA,SE
And White Space Splited data