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Simple Mendelian Randomization(Simple_MR)

THIS PROGRAM BUILD BY R 3.6 ver   


Need R library : 
	
	MendelianRandomization : an R package for performing Mendelian randomization 
				analyses using summarized data. O Yavorska, S Burgess  
	
	MRPRESSO : Detection of widespread horizontal pleiotropy in causal relationships 
		  inferred from Mendelian randomization between complex traits and diseases 
		  Nature Genetics volume 50, pages693–698(2018)   


Require OPTIONS                
-h | --help 	              print this help message 
-e | --Exposure      require  Exposure Summary statistics 
-o | --Outcome       require  Outcome Summary statistics 
-d | --OutDIRPrefix  require  Simple MR results out DIR Prefix, Make New Directory, Ansolute Pathway 		  
Optional OPTIONS for Exposure LD clumpling 		
-p | --Presso        optional YES or NO defualt YES, Deletion Outlier use MRPRESSO
-P | --plink 	     optional plink 1.9 program download by https://www.cog-genomics.org/plink2 
-b | --bfile         optional plink file format .bed .bim .fam for LD clumping. Used after the -P option.

input summary statistic file format 

Any format usefull! 

CAUTIONS  

but file head include by SNP,BETA,SE 

And White Space Splited data