Clarifications on Modifying Transporter Properties in PK-Sim Expression Profiles

[Zoe-Lau-NJ]

Dear Experts,

I hope this message finds you well. I have some questions regarding the modification of properties in the 'Expression Profile' section of PK-Sim. Specifically:

1. For common transporters like OAT3, is it necessary to modify these properties?
2. What does the 'Reference Concentration' refer to? Is it related to a specific concentration in the body?
3. Does the 'Half-Life' parameter indicate the protein's half-life?
4. Are these values typically retrieved from literature?

I would greatly appreciate your insights and guidance on these points. Thank you in advance for your time and support!