diff --git a/cpp/tensorrt_llm/common/envUtils.cpp b/cpp/tensorrt_llm/common/envUtils.cpp
index 4c1c41d5ae..a4fb013b2f 100644
--- a/cpp/tensorrt_llm/common/envUtils.cpp
+++ b/cpp/tensorrt_llm/common/envUtils.cpp
@@ -284,6 +284,23 @@ std::string getEnvUCXInterface()
     return ucxInterface;
 }
 
+std::string getEnvNixlInterface()
+{
+    static std::once_flag flag;
+    static std::string nixlInterface;
+
+    std::call_once(flag,
+        [&]()
+        {
+            char const* nixl_interface = std::getenv("TRTLLM_NIXL_INTERFACE");
+            if (nixl_interface)
+            {
+                nixlInterface = nixl_interface;
+            }
+        });
+    return nixlInterface;
+}
+
 bool getEnvDisaggLayerwise()
 {
     static bool const disaggLayerwise = getBoolEnv("TRTLLM_DISAGG_LAYERWISE");
diff --git a/cpp/tensorrt_llm/common/envUtils.h b/cpp/tensorrt_llm/common/envUtils.h
index 5a9dc27182..e85ee6468f 100644
--- a/cpp/tensorrt_llm/common/envUtils.h
+++ b/cpp/tensorrt_llm/common/envUtils.h
@@ -60,6 +60,8 @@ bool getEnvUseNixlKvCache();
 
 std::string getEnvUCXInterface();
 
+std::string getEnvNixlInterface();
+
 bool getEnvDisaggLayerwise();
 
 bool getEnvDisableSelectiveCacheTransfer();
diff --git a/cpp/tensorrt_llm/executor/cache_transmission/nixl_utils/transferAgent.cpp b/cpp/tensorrt_llm/executor/cache_transmission/nixl_utils/transferAgent.cpp
index 812f2af87a..721cade13a 100644
--- a/cpp/tensorrt_llm/executor/cache_transmission/nixl_utils/transferAgent.cpp
+++ b/cpp/tensorrt_llm/executor/cache_transmission/nixl_utils/transferAgent.cpp
@@ -22,15 +22,83 @@
 #include "tensorrt_llm/runtime/utils/mpiUtils.h"
 
 #include <arpa/inet.h>
+#include <dirent.h>
+#include <fcntl.h>
 #include <ifaddrs.h>
 #include <netdb.h>
 #include <netinet/in.h>
 #include <nixl_types.h>
+#include <sys/file.h>
+#include <sys/stat.h>
 #include <unistd.h>
+#include <vector>
 
 namespace tensorrt_llm::executor::kv_cache
 {
 
+class FileLock
+{
+private:
+    int fd_;
+    std::string lockFile_;
+    bool locked_;
+
+public:
+    explicit FileLock(std::string const& lockFile)
+        : fd_(-1)
+        , lockFile_(lockFile)
+        , locked_(false)
+    {
+    }
+
+    ~FileLock()
+    {
+        unlock();
+    }
+
+    bool lock()
+    {
+        if (locked_)
+            return true;
+
+        size_t pos = lockFile_.find_last_of('/');
+        if (pos != std::string::npos)
+        {
+            std::string dir = lockFile_.substr(0, pos);
+            mkdir(dir.c_str(), 0755);
+        }
+
+        fd_ = open(lockFile_.c_str(), O_CREAT | O_WRONLY, 0644);
+        if (fd_ == -1)
+        {
+            TLLM_LOG_ERROR("Failed to open lock file: %s", lockFile_.c_str());
+            return false;
+        }
+
+        if (flock(fd_, LOCK_EX) == -1)
+        {
+            TLLM_LOG_ERROR("Failed to acquire file lock: %s", lockFile_.c_str());
+            close(fd_);
+            fd_ = -1;
+            return false;
+        }
+
+        locked_ = true;
+        return true;
+    }
+
+    void unlock()
+    {
+        if (locked_ && fd_ != -1)
+        {
+            flock(fd_, LOCK_UN);
+            close(fd_);
+            fd_ = -1;
+            locked_ = false;
+        }
+    }
+};
+
 static std::string getAvailableIP()
 {
     struct ifaddrs *ifaddr, *ifa;
@@ -51,14 +119,14 @@ static std::string getAvailableIP()
         if (ifa->ifa_addr == nullptr)
             continue;
 
-        std::string ucxInterface = common::getEnvUCXInterface();
-        if (!ucxInterface.empty() && strcmp(ifa->ifa_name, ucxInterface.c_str()) != 0)
+        std::string nixlInterface = common::getEnvNixlInterface();
+        if (!nixlInterface.empty() && strcmp(ifa->ifa_name, nixlInterface.c_str()) != 0)
         {
             continue;
         }
 
         // Skip the loopback interface
-        if (ucxInterface.empty() && (strncmp(ifa->ifa_name, "docker", 6) == 0 || strcmp(ifa->ifa_name, "lo") == 0))
+        if (nixlInterface.empty() && (strncmp(ifa->ifa_name, "docker", 6) == 0 || strcmp(ifa->ifa_name, "lo") == 0))
         {
             continue;
         }
@@ -71,8 +139,8 @@ static std::string getAvailableIP()
             char address_buffer[INET_ADDRSTRLEN];
             inet_ntop(AF_INET, addr_ptr, address_buffer, sizeof(address_buffer));
 
-            TLLM_LOG_DEBUG(mpi::MpiComm::world().getRank(), " ***** UCX    Interface: %s IP Address: %s", ifa->ifa_name,
-                address_buffer);
+            TLLM_LOG_DEBUG(mpi::MpiComm::world().getRank(), " ***** NIXL    Interface: %s IP Address: %s",
+                ifa->ifa_name, address_buffer);
             ip = address_buffer;
             break;
         }
@@ -80,7 +148,7 @@ static std::string getAvailableIP()
     if (ifa == nullptr)
     {
         TLLM_LOG_ERROR(mpi::MpiComm::world().getRank(),
-            "UCX   No valid IP address found please set correct UCX interface with env variable TRTLLM_UCX_INTERFACE");
+            "UCX   No valid IP address found please set correct NIXL interface with env variable TRTLLM_UCX_INTERFACE");
     }
 
     freeifaddrs(ifaddr);
@@ -198,11 +266,18 @@ NixlTransferAgent::NixlTransferAgent(BaseAgentConfig const& config)
     : mName{config.mName}
 {
     nixl_status_t status;
-    auto envPort = common::getEnvNixlPort();
-    uint16_t port = envPort > 0 ? getIncrmentPort(envPort) : getAvailablePort();
-    nixlAgentConfig nixlConfig{config.useProgThread, true, port};
-    mAddress = getAvailableIP() + ":" + std::to_string(port);
-    mRawAgent = std::make_unique<nixlAgent>(config.mName, std::move(nixlConfig));
+    {
+        FileLock lock("/tmp/trtllm_nixl_port.lock");
+        if (!lock.lock())
+        {
+            TLLM_THROW("Failed to lock /tmp/trtllm_nixl_port.lock");
+        }
+        auto envPort = common::getEnvNixlPort();
+        uint16_t port = envPort > 0 ? getIncrmentPort(envPort) : getAvailablePort();
+        nixlAgentConfig nixlConfig{config.useProgThread, true, port};
+        mAddress = getAvailableIP() + ":" + std::to_string(port);
+        mRawAgent = std::make_unique<nixlAgent>(config.mName, std::move(nixlConfig));
+    }
 
     nixl_b_params_t init1;
     nixl_mem_list_t mems1;
@@ -337,6 +412,9 @@ void NixlTransferAgent::connectRemoteAgent(std::string const& name, ConnectionIn
 {
     std::string ip = connectionInfo.substr(0, connectionInfo.find(":"));
     std::string port = connectionInfo.substr(connectionInfo.find(":") + 1);
+    TLLM_LOG_DEBUG(mpi::MpiComm::world().getRank(),
+        "NixlTransferAgent::connectRemoteAgent connectRemoteAgent to %s remoteagent name: %s", connectionInfo.c_str(),
+        name.c_str());
     TLLM_CHECK_WITH_INFO(!ip.empty() && !port.empty(), "connectRemoteAgent get empty ip or port, connectionInfo: %s",
         connectionInfo.c_str());
     nixl_opt_args_t md_extra_params;