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Introduce 2-step classifier in alphaDIA scoring #397

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anna-charlotte opened this issue Dec 10, 2024 · 0 comments
Open

Introduce 2-step classifier in alphaDIA scoring #397

anna-charlotte opened this issue Dec 10, 2024 · 0 comments
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enhancement New feature or request

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@anna-charlotte
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WHO
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WHAT
Replace the current neural network scoring in alphaDIA with a two-step classifier (LDA + NN).

WHY
Preselect precursors before NN training to speed up training and improve FDR sensitivity.

Acceptance Criteria
The solution must achieve at least the same FDR while reducing training time, but ideally should also improve FDR sensitivity by enabling better identification.

Additional information
The two-step classifier approach is inspired by DIA-NN by Demichev et al., as outlined in their Methods section.

@anna-charlotte anna-charlotte self-assigned this Dec 10, 2024
@mschwoer mschwoer added the enhancement New feature or request label Dec 16, 2024
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