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Phenotype definitions

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gracemarionpower edited this page Dec 6, 2024 · 28 revisions

We are currently including the following set of phenotypes in this analysis round. To be included a cohort will need to provide at least one phenotype. The list is somewhat aspirational and if bandwidth limits the number of phenotypes that can be contributed, that is fine.

Anthropometric

Body Mass Index (BMI)

  • Units: kilograms/metres^2 (kg/m2)
  • Covariates: sex

Note: These data will also be used to calculate BMI-for-age z-scores, applying the WHO growth reference standards for individuals aged 0 to 19 years. This standardised approach ensures accurate age- and sex-specific assessments based on internationally recognised benchmarks.

Height

  • Definition: Standing height
  • Units: centimeters (cm)
  • Covariates: sex

Note: These data will also be used to calculate height-for-age z-scores, applying the WHO growth reference standards for individuals aged 0 to 19 years. This standardised approach ensures accurate age- and sex-specific assessments based on internationally recognised benchmarks.

Waist circumference

  • Units: centimeters (cm)
  • Covariates: sex

Waist to hip ratio (WHR)

  • Definition: Divide the waist measurement (cm) by hip measurement (cm) (cm/cm)
  • Units: Absolute ratio
  • Covariates: sex

Bone mineral density (BMD)

  • Definition: Total body bone mineral density (TB-BMD) measured using Dual-Energy X-ray Absorptiometry (DXA) scanning equipment.
  • Units: grams/centimeters^2 (g/cm2)
  • Covariates: sex

Lung function

Forced expiratory volume in 1 second (FEV1)

  • Units: Litres (l)
  • Covariates: sex

 FEV1/FVC ratio

  • Definition: Ratio of Forced expiratory volume in 1 second (litres) to Forced Vital Capacity (litres)
  • Units: Please state whether absolute ratio value or Z-scores are being provided.
  • Covariates: sex

Cardiovascular

Systolic blood pressure (SBP)

  • Definition: Automated reading
  • Units: millimetres of mercury (mmHg)
  • Covariates: sex, blood pressure medication (bp_med; Yes = 1, No =0).
  • We will adjust for blood pressure medication by applying a a constant increase of 15mmHg in individuals taking medication.

Diastolic blood pressure (DBP)

  • Definition: Automated reading
  • Units: millimetres of mercury (mmHg)
  • Covariates: sex, blood pressure medication (bp_med; Yes = 1, No =0).
  • We will adjust for blood pressure medication by applying a a constant increase of 15mmHg in individuals taking medication.

Blood measures

Low density lipoprotein (LDL) cholesterol

  • Definition: blood measure
  • Units: millimoles per liter (mmol/L)
  • Covariates: sex, statin medication use (cholesterol_med; 1 = Yes, 0 = No), insulin medication use (diabetes_status:insulin_medication; Yes = 1, No = 0) We will adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.

High density lipoprotein (HDL) cholesterol

  • Definition: blood measure
  • Units: millimoles per liter (mmol/L)
  • Covariates: sex, statin medication use (cholesterol_med; 1 = Yes, 0 = No).
  • We will adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.

Triglycerides

  • Definition: blood measure
  • Units: millimoles per liter (mmol/L)
  • Covariates: sex, statin medication use (cholesterol_med; 1 = Yes, 0 = No).
  • We will adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.

Glycated haemoglobin (HbA1c)

  • Definition: blood measure
  • Units: millimoles per liter (mmol/L)
  • Covariates: sex, insulin medication use (diabetes_status:insulin_medication; Yes = 1, No = 0).
  • We will adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.

Leptin

  • Definition: blood measure
  • Units: nanogram per milliliter (ng/ml)
  • Covariates: sex

Insulin

  • Definition: blood measure. Conversion factor 1 μIU/mL = 6.00 pmol/L.
  • Units: pmol/L
  • Covariates: sex, insulin medication use (diabetes_status:insulin_medication; Yes = 1, No = 0).
  • We will adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.

Adiponectin

  • Definition: blood measure
  • Units: micrograms per milliliter (μg/ml)
  • Covariates: sex

Calcium

  • Definition: blood measure
  • Units: millimoles per liter (mmol/L)
  • Covariates: sex, statin medication use (cholesterol_med; 1 = Yes, 0 = No).
  • We will adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.

Vitamin D

  • Definition: blood measure
  • Units: nanomoles per liter (nmol/L)
  • Covariates: sex

Immune markers

C-reactive protein (CRP)

  • Definition: blood measure
  • Units: milligrams per liter (mg/L)
  • Covariates: sex, medication for cholesterol (cholesterol_med; 1 = Yes, 0 = No).
  • We will adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.

Interleukin-6 (Il6)

  • Definition: blood measure
  • Units: picograms per millilitre (pg/ml)
  • Covariates: sex

Sex hormones

Estradiol

  • Definition: blood measure
  • Units: picomoles per liter (pmol/L)
  • Covariates: sex, hormonal contraception (1 = Yes, 0 = No), hormone replacement therapy (1 = Yes, 0 = No)
  • We will not adjust for hormonal contraception/hormone replacement therapy since this is likely to significantly reduce sample sizes available for collection. We will conduct a sensitivity analysis at the meta-analysis stage, to assess whether potential heterogeneity in GxAge interaction effects observed are attributed to drug use.

Testosterone

  • Definition: Total testosterone, blood measure

  • Units: nanomoles per liter (nmol/L)

  • Covariates: sex

  • We will not adjust for hormonal contraception/hormone replacement therapy since this is likely to significantly reduce sample sizes available for collection. We will conduct a sensitivity analysis at the meta-analysis stage, to assess whether potential heterogeneity in GxAge interaction effects observed are attributed to drug use.

  • Definition: Bioavailable testosterone, blood measure

  • Units: nanomoles per liter (nmol/L)

  • Covariates: sex

  • We will not adjust for hormonal contraception/hormone replacement therapy since this is likely to significantly reduce sample sizes available for collection. We will conduct a sensitivity analysis at the meta-analysis stage, to assess whether potential heterogeneity in GxAge interaction effects observed are attributed to drug use.

Sex hormone binding globulin

  • Definition: blood measure
  • Units: nanomoles per liter (nmol/L)
  • Covariates: sex
  • We will not adjust for hormonal contraception/hormone replacement therapy since this is likely to significantly reduce sample sizes available for collection. We will conduct a sensitivity analysis at the meta-analysis stage, to assess whether potential heterogeneity in GxAge interaction effects observed are attributed to drug use.
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