Phenotype definitions

We are currently including the following set of phenotypes in this analysis round. To be included a cohort will need to provide at least one phenotype. The list is somewhat aspirational and if bandwidth limits the number of phenotypes that can be contributed, that is fine.

Anthropometric

Body Mass Index (BMI)

• Units: kilograms/metres^2 (kg/m2)
• Covariates: sex

Note: These data will also be used to calculate BMI-for-age z-scores, applying the WHO growth reference standards for individuals aged 5 to 19 years. This standardised approach ensures accurate age- and sex-specific assessments based on internationally recognised benchmarks.

Height

• Definition: Standing height
• Units: centimeters (cm)
• Covariates: sex

Waist circumference

• Units: centimeters (cm)
• Covariates: sex

Waist to hip ratio (WHR)

• Definition: Divide the waist measurement (cm) by hip measurement (cm) (cm/cm)
• Units: Absolute ratio
• Covariates: sex

Bone mineral density

• Definition: Measured using Dual-Energy X-ray Absorptiometry (DXA) scanning equipment. Assess the whole body minus the head. Reported as whole-body areal bone mineral density (aBMD).
• Units: grams/centimeters^2 (g/cm2)
• Covariates: sex

Lung function

Forced expiratory volume in 1 second (FEV1)

• Units: Litres (l)
• Covariates: sex

 FEV1/FVC ratio

• Definition: Ratio of Forced expiratory volume in 1 second (litres) to Forced Vital Capacity (litres)
• Units: Please state whether absolute ratio value or Z-scores are being provided.
• Covariates: sex

Cardiovascular

Systolic blood pressure (SBP)

• Definition: Automated reading
• Units: millimetres of mercury (mmHg)
• Adjustments: adjust for blood pressure medication. Applying a constant increase of 15mmHg in individuals taking medication.
• Covariates: sex

Diastolic blood pressure (DBP)

• Definition: Automated reading
• Units: millimetres of mercury (mmHg)
• Adjustments: adjust for blood pressure medication. Applying a constant increase of 15mmHg in individuals taking medication.
• Covariates: sex

Blood measures

Low density lipoprotein (LDL) cholesterol

• Definition: blood measure
• Units: millimoles per liter (mmol/L)
• Adjustments: adjust for statin/cholesterol lowering medication by applying a relative reduction to the measured value of 40%.
• Covariates: sex

High density lipoprotein (HDL) cholesterol

• Definition: blood measure
• Units: millimoles per liter (mmol/L)
• Adjustments: cholesterol_med
• Covariates: sex

Triglycerides

• Definition: blood measure
• Units: millimoles per liter (mmol/L)
• Adjustments: cholesterol_med
• Covariates: sex

Glycated haemoglobin (HbA1c)

• Definition: blood measure
• Units: millimoles per liter (mmol/L)
• Adjusments: diabetes_status:insulin_medication
• Covariates: sex

Leptin

• Definition: blood measure
• Units: nanogram per milliliter (ng/ml)
• Covariates: sex

Insulin

• Definition: blood measure. Conversion factor 1 μIU/mL = 6.00 pmol/L.
• Units: pmol/L
• Adjustments: diabetes_status:insulin_medication
• Covariates: sex

Adiponectin

• Definition: blood measure
• Units: micrograms per milliliter (μg/ml)
• Covariates: sex

Calcium

• Definition: blood measure
• Units: millimoles per liter (mmol/L)
• Adjustments: cholesterol_med
• Covariates: sex

Vitamin D

• Definition: blood measure
• Units: nanomoles per liter (nmol/L)
• Covariates: sex

Immune markers

C-reactive protein (CRP)

• Definition: blood measure
• Units: milligrams per liter (mg/L)
• Adjustments: cholesterol_med
• Covariates: sex

Interleukin-6 (Il6)

• Definition: blood measure
• Units: picograms per millilitre (pg/ml)
• Covariates: sex

Sex hormones

Estradiol

• Definition: blood measure
• Units: picomoles per liter (pmol/L)
• Adjustments: apply constant for hormonal contraception use, and hormone replacement therapy
• Covariates: sex, age of menarche, parity (number of offspring) and age at menopause

Testosterone

• Definition: blood measure
• Units: nanomoles per liter (nmol/L)
• Adjustments: apply constant for hormonal contraception use, and hormone replacement therapy
• Covariates: sex, age of menarche, parity (number of offspring) and age at menopause

Sex hormone binding globulin

• Definition: blood measure
• Units: nanomoles per liter (nmol/L)
• Adjustments: apply constant for hormonal contraception use, and hormone replacement therapy
• Covariates: sex, age of menarche, parity (number of offspring) and age at menopause