diff --git a/Formula/i/ispc.rb b/Formula/i/ispc.rb
index 39e79c73c012e..51d4718426dd2 100644
--- a/Formula/i/ispc.rb
+++ b/Formula/i/ispc.rb
@@ -1,10 +1,9 @@
 class Ispc < Formula
   desc "Compiler for SIMD programming on the CPU"
   homepage "https://ispc.github.io"
-  url "https://github.com/ispc/ispc/archive/refs/tags/v1.24.0.tar.gz"
-  sha256 "a45ec5402d8a3b23d752125a083fa031becf093b8304ccec55b1c2f37b5479c3"
+  url "https://github.com/ispc/ispc/archive/refs/tags/v1.25.2.tar.gz"
+  sha256 "745cc8bcde26e63af2700f1811b66d2ca66b2844c8e2aa9ac19c12ab6a39b82a"
   license "BSD-3-Clause"
-  revision 1
 
   # Upstream sometimes creates releases that use a stable tag (e.g., `v1.2.3`)
   # but are labeled as "pre-release" on GitHub, so it's necessary to use the
@@ -15,19 +14,19 @@ class Ispc < Formula
   end
 
   bottle do
-    sha256 cellar: :any,                 arm64_sequoia: "d650f99ada33e330e23eaac7f517fabef65976ed7ee5b92cfca56e5208f7a2fb"
-    sha256 cellar: :any,                 arm64_sonoma:  "c7a0754f38ea0957194c08777b6f3e4735e99ab10de1485f4f668ef32ae6e2fc"
-    sha256 cellar: :any,                 arm64_ventura: "d490a9505d3fdcff68e78b98208818716f6a5d38982f7a65fd634094c4bd2bda"
-    sha256 cellar: :any,                 sonoma:        "80a689f14d9c006eb0301b64cccd6a5e7d23c84bce4637ae0c6d29fc66abec2d"
-    sha256 cellar: :any,                 ventura:       "a23c36580e65097630847b2c9ee3ca2815a5eddda847f3def225fbf4738f832b"
-    sha256 cellar: :any_skip_relocation, x86_64_linux:  "dcd08c7b19eef4617e2c0c7cffa482deb8ad588bb46e2b1bc1852c146b041256"
+    sha256 cellar: :any, arm64_sequoia: "b0f72091d48f949e719772d717989af9cd169f6f89a890702b0104a02752395c"
+    sha256 cellar: :any, arm64_sonoma:  "c7a09a3f7c4204420de15636a254ddac95d3e43fbddcab1aa6b6c85b250245c5"
+    sha256 cellar: :any, arm64_ventura: "164b88b15ba40aaa2fa6bf1a48175a0702d07f0f2dd0959f505633d5fd638478"
+    sha256 cellar: :any, sonoma:        "7945def3908530673b9e6e3b20484734613ed5716180c0d080f8142eff99c329"
+    sha256 cellar: :any, ventura:       "2d802a069f6014fbce7666f9ed2bf5fa978c38d4fcd3445fd3ba2b4b4b7de308"
   end
 
   depends_on "bison" => :build
   depends_on "cmake" => :build
   depends_on "flex" => :build
-  depends_on "python@3.12" => :build
-  depends_on "llvm@18"
+  depends_on "llvm"
+
+  uses_from_macos "python" => :build
 
   on_linux do
     depends_on "tbb"
@@ -40,13 +39,6 @@ def llvm
   end
 
   def install
-    # Force cmake to use our compiler shims instead of bypassing them.
-    inreplace "CMakeLists.txt", "set(CMAKE_C_COMPILER \"clang\")", "set(CMAKE_C_COMPILER \"#{ENV.cc}\")"
-    inreplace "CMakeLists.txt", "set(CMAKE_CXX_COMPILER \"clang++\")", "set(CMAKE_CXX_COMPILER \"#{ENV.cxx}\")"
-
-    # Disable building of i686 target on Linux, which we do not support.
-    inreplace "cmake/GenerateBuiltins.cmake", "set(target_arch \"i686\")", "return()" unless OS.mac?
-
     args = %W[
       -DISPC_INCLUDE_EXAMPLES=OFF
       -DISPC_INCLUDE_TESTS=OFF