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Development Roadmap

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melissacline edited this page Oct 26, 2017 · 39 revisions

This section links to material on the changes and new functionality planned or underway for BRCA Exchange development.

This page is updated quarterly. To get the most recent roadmap, please see our Waffleboard.

Big Picture

  • Here are notes from a brainstorming meeting on upcoming development priorities.

  • The UCSC and ETH Zurch BRCA Exchange teams held a joint meeting in Santa Cruz on Aug 21-23, 2017. Here are some planning notes, the meeting agenda, and meeting report with slides.

Portal Development

  • Mobile app (Faisal)

  • Restructure the help pages. Here is a Google drive with patient-focused material. Here is an outline of questions to ask of stakeholders such as patient advocates (Amy). And here is a recent draft.

  • Literature search: currently refining the method for production (Audrey, Chloe).

  • BRCA Exchange / MuPIT integration (Melissa)

  • Implement BRCA Exchange News (see the wireframes). (Charlie)

  • Expand the suite of unit tests (Collin)

Collecting and presenting variant-level evidence

Splicing and prediction of truncation

  • Team Splicing is gathering the ingredients for computing the splicing prior, including predicting truncating variants (Tyler, Melissa M, Luis). These documents describe respectively the method and the data, and this document shows wireframes for splicing data visualization. Finally, this document lists pseudocode for calculating the priors (Chloe).

Gathering and presenting allele frequency data

  • Incorporating data from gnomAD: Awaiting the release of "gnomAD minus TCGA" (Sam)

Collecting case-level evidence

Analysis Types

Data collection issues

  • Parsing text data from images of reports

    • OCR methods (Chloe).
    • We have some scans of blank test order forms here

  • Managing redundancy: one-way cryptographic hashes (Johnnie)

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